BACH2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3OHU, 3OHV

Identifiers

Aliases

BACH2, BTBD25, BTB domain and CNC homolog 2

External IDs

MGI: 894679 HomoloGene: 7240 GeneCards: BACH2

Genetically Related Diseases

type 1 diabetes mellitus, Obesity, vitiligo, multiple sclerosis, Crohn's disease, celiac disease

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin-protein transferase activity
Cellular component	• cytoplasm • Cul3-RING ubiquitin ligase complex • nucleus • cytosol
Biological process	• regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • protein ubiquitination • single-organism nuclear import
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


60468


12014

Ensembl


ENSG00000112182


ENSMUSG00000040270

UniProt


Q9BYV9


P97303

RefSeq (mRNA)


NM_001170794 NM_021813


NM_001109661 NM_007521

RefSeq (protein)


NP_001164265 NP_068585


NP_001103131.1 NP_001103131

Location (UCSC)

Chr 6: 89.93 – 90.3 Mb

Chr 4: 32.24 – 32.59 Mb

PubMed search

NM_001170794
NM_021813

NM_001109661
NM_007521

NP_001164265
NP_068585

NP_001103131.1
NP_001103131

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus.

Model organisms have been used in the study of BACH2 function. A conditional knockout mouse line called Bach2^{tm1a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

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