BACH1

BACH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IHC
Identifiers
Aliases	BACH1, BACH-1, BTBD24, BTB domain and CNC homolog 1
External IDs	MGI: 894680 HomoloGene: 916 GeneCards: BACH1
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • ubiquitin-protein transferase activity • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • heme binding Cellular component • cytoplasm • cytosol • Cul3-RING ubiquitin ligase complex • nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription involved in G1/S transition of mitotic cell cycle • GO:0006350 transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to hypoxia • DNA repair • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription involved in G2/M transition of mitotic cell cycle • protein ubiquitination • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	571	12013
Ensembl	ENSG00000156273	ENSMUSG00000025612
UniProt	O14867	P97302
RefSeq (mRNA)	NM_001011545 NM_001186 NM_206866	NM_007520
RefSeq (protein)	NP_001177 NP_996749	NP_031546.1 NP_031546
Location (UCSC)	Chr 21: 29.19 – 29.63 Mb	Chr 16: 87.7 – 87.73 Mb
PubMed search

2IHC

571

12013

ENSG00000156273

ENSMUSG00000025612

O14867

P97302

NM_001011545
NM_001186
NM_206866

NM_007520

NP_001177
NP_996749

NP_031546.1
NP_031546

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.

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