"Ayo Technology" is the fourth single from 50 Cent's third album, Curtis. The song, featuring Justin Timberlake and uncredited vocals from Timbaland, who also produced the song, peaked at number five on the Billboard Hot 100. Internationally, the song peaked within the top ten of the charts in many countries, including Australia, Denmark and the United Kingdom. The song has since been covered by Milow, a Belgian singer-songwriter whose version was successful in a number of countries, including Belgium, Spain, Germany, Italy, and the Netherlands. The song was also covered by Skyla, a British singer-songwriter whose version was popular in the dance genre and Katerine Avgoustakis, another Belgian singer, whose version was successful in Poland.

HipHopDX reported that the song was renamed three times. It was first titled "Ayo Pornography" when it first leaked in May 2007, then "Ayo Technology" in June, and then "She Wants It" by July. Finally, the song title was reverted to "Ayo Technology." The song features Justin Timberlake and Timbaland, but most sources don't credit Timbaland for being on the song. In 2008, it was nominated for a Grammy for Best Rap Song. As revealed within its lyrics, "Ayo Technology" puts a strong emphasis on hot-blooded sexual fantasies, explicit body movements (such as when Timberlake utters the line "Why don't you sit down on top of me") and wild festivities at nightclubs. The intro and lead synth were created using an emulated version of the MOS SID Synthesizer microchip used in the Commodore 64 8-bit Home Computer, on the Open Labs Neko Digital Audio Workstation that Timbaland was famous for using around this period.. Because of this, it is remarkably similar-sounding to the electronic music duo Crystal Castles' "Courtship Dating" from their self-titled album, released the following year although performed live since December 2006. Despite the album itself not being out until nearly a year after the public debut of "Ayo Technology," there was still minor controversy over the alleged "sampling" of this song on "Ayo Technology", perhaps because of the negative reputation Timbaland has garnered over sampling uncredited 8-bit musicians.

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