Avian sarcoma leukosis virus
| Avian Sarcoma Leukosis Virus | |
|---|---|
| Virus classification | |
| Group: | Group VI (ssRNA-RT) |
| Order: | Unassigned |
| Family: | Retroviridae |
| Subfamily: | Orthoretrovirinae |
| Genus: | Alpharetrovirus |
| Species: | Avian leukosis virus |
Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals. ASLV replicates in chicken embryo fibroblasts, the cells that contribute to the formation of connective tissues. Different forms of the disease exist, including lymphoblastic, erythroblastic, and osteopetrotic.
Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. Lymphoid leukosis is the most common form of this disease and with typical presentation of gradual onset, persistent low mortality, and neoplasia of the bursa. The disease is also characterized by an enlarged liver due to infiltration of cancerous lymphoid cells. In addition, other abdominal organs and the bursa of Fabricius are often infected.
Lymphoid leukosis has a worldwide distribution, and is most commonly found in birds 16 weeks or older.
Sarcoma in chickens has been studied since the early 1900s when Ellerman and Bang demonstrated that erythroleukemia can be transmitted between chickens by cell-free tissue filtrates, and in 1911 when (Francis) Peyton Rous proved that sarcoma can be transmitted through cell free extracts of solid chicken tumors. Rous was awarded the Nobel Prize for his discovery in 1966.
By the 1960s, ASLV became a problem with egg-laying hens and effort was made to isolate the disease. However, the movement was unsuccessful in maintaining leukosis-free flocks. In 1961, Rous sarcoma virus (RSV), which is closely related to ASLV, was shown to contain RNA, and oncogenic viruses, such as RSV and ASLV, were termed RNA tumor viruses. By the late 1960s, Howard Temin hypothesized that RSV made a copy of its own DNA and integrated that into the host cell’s chromosomal DNA. Much debate in the scientific community surrounded this issue until DNA integration was demonstrated by Temin in 1968 and reverse transcriptase was independently discovered by both Temin and David Baltimore in 1970. Temin and Baltimore won the Nobel Prize in Medicine in 1975.
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