Autoimmune regulator

AIRE

PBB Protein AIRE image.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LRI, 1XWH, 2KE1, 2KFT

Identifiers

AIRE, AIRE1, APECED, APS1, APSI, PGA1, autoimmune regulator

External IDs

OMIM: 607358 MGI: 1338803 HomoloGene: 327 GeneCards: AIRE

Gene ontology
Molecular function	• DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • histone binding • zinc ion binding • chromatin binding • transcription cofactor activity • translation regulator activity • metal ion binding • protein binding • identical protein binding • transcription regulatory region DNA binding
Cellular component	• cytoplasm • intracellular • nuclear body • nucleus
Biological process	• regulation of transcription, DNA-templated • transcription, DNA-templated • negative thymic T cell selection • humoral immune response • immune response • regulation of translation • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • peripheral T cell tolerance induction • central tolerance induction to self antigen • chemokine production • positive regulation of transcription, DNA-templated • thymus epithelium morphogenesis • regulation of thymocyte migration
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE AIRE 208090 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


326


11634


ENSG00000160224


ENSMUSG00000000731


O43918


Q9Z0E3

RefSeq (mRNA)


NM_000383 NM_000658 NM_000659

NM_001271549 NM_001271550 NM_001271551 NM_001271552 NM_001271553
NM_001271554 NM_001271555 NM_001271556 NM_001271557 NM_001271558 NM_001271559 NM_009646

RefSeq (protein)


NP_000374

NP_001258478.1 NP_001258479.1 NP_001258480.1 NP_001258481.1 NP_001258482.1
NP_001258483.1 NP_001258484.1 NP_001258485.1 NP_001258486.1 NP_001258487.1 NP_001258488.1 NP_033776.1 NP_001258478 NP_001258479 NP_001258480 NP_001258481 NP_001258482 NP_001258483 NP_001258484 NP_001258485 NP_001258486 NP_001258487 NP_001258488 NP_033776

Location (UCSC)

Chr 21: 44.29 – 44.3 Mb

Chr 10: 78.03 – 78.04 Mb

PubMed search

2LRI, 1XWH, 2KE1, 2KFT

ENSG00000160224

ENSMUSG00000000731

NM_000383
NM_000658
NM_000659

NM_001271554
NM_001271555
NM_001271556
NM_001271557
NM_001271558
NM_001271559
NM_009646

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Wikipedia

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