August Franz Josef Karl Mayer (2 November 1787 in Schwäbisch Gmünd – 9 November 1865 in Bonn) was a German anatomist and physiologist.
He received his education at the University of Tübingen, obtaining his doctorate in 1812. Afterwards, he worked as a prosector at the Academy of Bern, where in 1815 he was named a professor of anatomy and physiology. From 1819 to 1856 he was a professor at the University of Bonn. Among his better known students at Bonn were Johannes Peter Müller and Theodor Ludwig Wilhelm von Bischoff.
His name is associated with a female reproductive disorder known today as Mayer-Rokitansky-Küster-Hauser syndrome (MRKH); named in conjunction with Carl von Rokitansky, Hermann Küster and Georges André Hauser.
He was the author of around 145 published works, many of them written from the viewpoint of natural philosophy.