Atrial natriuretic factor

NPPA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ANP, 1YK0, 3N57
Identifiers
Aliases	NPPA, ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND, Atrial natriuretic peptide, natriuretic peptide A
External IDs	OMIM: 108780 MGI: 97367 HomoloGene: 4498 GeneCards: NPPA
Gene ontology Molecular function • neuropeptide receptor binding • hormone activity • peptide hormone receptor binding • neuropeptide hormone activity • protein binding • receptor binding Cellular component • cytoplasm • mast cell granule • nucleus • perinuclear region of cytoplasm • extracellular region • extracellular space • protein complex Biological process • response to muscle stretch • positive regulation of cardiac muscle contraction • response to hypoxia • regulation of high voltage-gated calcium channel activity • neuropeptide signaling pathway • female pregnancy • regulation of cardiac conduction • negative regulation of collecting lymphatic vessel constriction • positive regulation of potassium ion export across plasma membrane • cellular protein metabolic process • regulation of blood vessel size • positive regulation of heart rate • positive regulation of delayed rectifier potassium channel activity • cGMP biosynthetic process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • regulation of calcium ion transmembrane transport via high voltage-gated calcium channel • transcription initiation from RNA polymerase II promoter • regulation of atrial cardiac muscle cell membrane repolarization • response to insulin • cell growth involved in cardiac muscle cell development • negative regulation of cell growth • cardiac muscle hypertrophy in response to stress • cellular response to mechanical stimulus • receptor guanylyl cyclase signaling pathway • protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4878	230899
Ensembl	ENSG00000175206	ENSMUSG00000041616
UniProt	P01160	P05125
RefSeq (mRNA)	NM_006172	NM_008725
RefSeq (protein)	NP_006163	NP_032751.1 NP_032751
Location (UCSC)	Chr 1: 11.85 – 11.85 Mb	Chr 4: 148 – 148 Mb
PubMed search

1ANP, 1YK0, 3N57

4878

230899

ENSG00000175206

ENSMUSG00000041616

P01160

P05125

NM_006172

NM_008725

NP_006163

NP_032751.1
NP_032751

Atrial natriuretic peptide (ANP), also called atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), cardionatrine, cardiodilatin (CDD), or atriopeptin, is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood volume. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP has exactly the opposite function of the aldosterone secreted by the zona glomerulosa in regard to its effect on sodium in the kidney – that is, aldosterone stimulates sodium retention and ANP generates sodium loss.

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