Arachidonate 15-lipoxygenase-1

ALOX15
Identifiers
Aliases	ALOX15, 12-LOX, 15-LOX-1, 15LOX-1, arachidonate 15-lipoxygenase, 15-LOX, LOG15
External IDs	MGI: 87997 HomoloGene: 44935 GeneCards: ALOX15
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 4,630,902 bp End 4,642,294 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B3|11 42.99 cM Start 70,344,152 bp End 70,352,031 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hepoxilin A3 synthase activity • iron ion binding • eoxin A4 synthase activity • dioxygenase activity • hepoxilin-epoxide hydrolase activity • metal ion binding • protein binding • oxidoreductase activity • phosphatidylinositol-4,5-bisphosphate binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • lipid binding • arachidonate 15-lipoxygenase activity • arachidonate 12-lipoxygenase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • lipid droplet • plasma membrane Biological process • cellular response to calcium ion • bone mineralization • leukotriene metabolic process • positive regulation of heterotypic cell-cell adhesion • positive regulation of actin filament polymerization • negative regulation of adaptive immune response • ossification • lipoxin A4 biosynthetic process • lipid metabolic process • wound healing • phosphatidylethanolamine biosynthetic process • regulation of peroxisome proliferator activated receptor signaling pathway • response to endoplasmic reticulum stress • fatty acid metabolic process • apoptotic cell clearance • lipoxygenase pathway • hepoxilin biosynthetic process • regulation of engulfment of apoptotic cell • positive regulation of ERK1 and ERK2 cascade • inflammatory response • oxidation-reduction process • cellular response to interleukin-13 • positive regulation of cell-substrate adhesion • arachidonic acid metabolic process • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246	11687
Ensembl	ENSG00000161905	ENSMUSG00000018924
UniProt	P16050	P39654
RefSeq (mRNA)	NM_001140	NM_009660
RefSeq (protein)	NP_001131	NP_033790
Location (UCSC)	Chr 17: 4.63 – 4.64 Mb	Chr 11: 70.34 – 70.35 Mb
PubMed search

246

11687

ENSG00000161905

ENSMUSG00000018924

P16050

P39654

NM_001140

NM_009660

NP_001131

NP_033790

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. ▼ Gene Function

Kelavkar and Badr (1999) stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. These studies defined a direct link between ALOX15 gene activity and an established tumor-suppressor gene located in close chromosomal proximity. Kelavkar and Badr (1999) referred to this as evidence that 15-lipoxygenase is a mutator gene. ▼ Mapping

By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10.

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