Apolipoprotein H

APOH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C1Z, 1G4F, 1G4G, 1QUB, 2KRI, 3OP8, 4JHS
Identifiers
Aliases	APOH, B2G1, B2GP1, BG, apolipoprotein H
External IDs	OMIM: 138700 MGI: 88058 HomoloGene: 26 GeneCards: APOH
Gene ontology Molecular function • heparin binding • lipoprotein lipase activator activity • glycoprotein binding • protein binding • identical protein binding • phospholipid binding • lipid binding Cellular component • extracellular matrix • chylomicron • very-low-density lipoprotein particle • high-density lipoprotein particle • extracellular exosome • platelet dense granule lumen • extracellular region • extracellular space • cell surface Biological process • blood coagulation, intrinsic pathway • negative regulation of fibrinolysis • negative regulation of blood coagulation • positive regulation of lipoprotein lipase activity • negative regulation of endothelial cell migration • negative regulation of endothelial cell proliferation • positive regulation of blood coagulation • negative regulation of angiogenesis • triglyceride transport • plasminogen activation • regulation of blood coagulation • negative regulation of myeloid cell apoptotic process • regulation of fibrinolysis • triglyceride metabolic process • negative regulation of smooth muscle cell apoptotic process • platelet degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	350	11818
Ensembl	ENSG00000091583	ENSMUSG00000000049
UniProt	P02749	Q01339
RefSeq (mRNA)	NM_000042	NM_013475
RefSeq (protein)	NP_000033	NP_038503.4 NP_038503
Location (UCSC)	Chr 17: 66.21 – 66.26 Mb	Chr 11: 108.34 – 108.41 Mb
PubMed search

Sushi_2
NMR structure of the fifth domain of human beta-2-glycoprotein I
Identifiers
Symbol	Sushi_2
Pfam	PF09014
InterPro	IPR015104
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1C1Z, 1G4F, 1G4G, 1QUB, 2KRI, 3OP8, 4JHS

350

11818

ENSG00000091583

ENSMUSG00000000049

P02749

Q01339

NM_000042

NM_013475

NP_000033

NP_038503.4
NP_038503

Apolipoprotein H (Apo-H), previously known as (β₂-glycoprotein I, beta-2 glycoprotein I), is a 38 kDa multifunctional apolipoprotein that in humans is encoded by the APOH gene. One of its functions is to bind cardiolipin. When bound the structure of cardiolipin and Apo-H both undergo large changes in structure. Within the structure of Apo-H is a stretch of positively charged amino acids, (protein sequence positions 282-287) Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding (See image on right).