Apolipoprotein E

APOE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B
Identifiers
Aliases	APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E
External IDs	OMIM: 107741 MGI: 88057 HomoloGene: 30951 GeneCards: APOE
Genetically Related Diseases
Alzheimer's disease, microcephaly
Gene ontology Molecular function • heparin binding • very-low-density lipoprotein particle receptor binding • low-density lipoprotein particle receptor binding • lipoprotein particle binding • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • cholesterol transporter activity • protein homodimerization activity • beta-amyloid binding • protein binding • tau protein binding • metal chelating activity • lipid transporter activity • cholesterol binding • antioxidant activity • identical protein binding • lipid binding Cellular component • cytoplasm • membrane • chylomicron • extracellular region • nucleus • extracellular vesicle • endocytic vesicle lumen • very-low-density lipoprotein particle • • endoplasmic reticulum • extracellular exosome • Golgi apparatus • blood microparticle • extracellular matrix • plasma membrane • neuronal cell body • early endosome • low-density lipoprotein particle • dendrite • high-density lipoprotein particle • intermediate-density lipoprotein particle Biological process • negative regulation of neuron apoptotic process • response to dietary excess • negative regulation of lipid transport across blood brain barrier • lipid transport • positive regulation of lipid biosynthetic process • regulation of axon extension • positive regulation of postsynaptic membrane organization • positive regulation of cholesterol esterification • phospholipid efflux • cholesterol catabolic process • positive regulation of dendritic spine development • receptor-mediated endocytosis • retinoid metabolic process • positive regulation of beta-amyloid formation • lipid homeostasis • lipoprotein biosynthetic process • cholesterol homeostasis • negative regulation of inflammatory response • triglyceride metabolic process • negative regulation of canonical Wnt signaling pathway • negative regulation of dendritic spine maintenance • negative regulation of blood vessel endothelial cell migration • NMDA glutamate receptor clustering • response to reactive oxygen species • negative regulation of blood coagulation • positive regulation of cGMP biosynthetic process • response to oxidative stress • positive regulation of nitric-oxide synthase activity • negative regulation of phospholipid efflux • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • artery morphogenesis • very-low-density lipoprotein particle remodeling • regulation of neuronal synaptic plasticity • cardiovascular system development • negative regulation of dendritic spine development • negative regulation of cholesterol biosynthetic process • positive regulation of dendritic spine maintenance • positive regulation of phospholipid efflux • negative regulation of presynaptic membrane organization • negative regulation of neuron death • high-density lipoprotein particle clearance • long-chain fatty acid transport • lipoprotein metabolic process • regulation of tau-protein kinase activity • G-protein coupled receptor signaling pathway • chylomicron remnant clearance • cellular calcium ion homeostasis • cholesterol metabolic process • very-low-density lipoprotein particle clearance • virion assembly • negative regulation of lipid biosynthetic process • cGMP-mediated signaling • triglyceride catabolic process • positive regulation of presynaptic membrane organization • positive regulation of neurofibrillary tangle assembly • AMPA glutamate receptor clustering • positive regulation of low-density lipoprotein particle receptor catabolic process • positive regulation of lipid transport across blood brain barrier • fatty acid homeostasis • nitric oxide mediated signal transduction • transport • cholesterol efflux • regulation of gene expression • negative regulation of cholesterol efflux • regulation of beta-amyloid clearance • neuron projection regeneration • negative regulation of postsynaptic membrane organization • steroid metabolic process • regulation of Cdc42 protein signal transduction • lipid metabolic process • negative regulation of beta-amyloid formation • positive regulation of membrane protein ectodomain proteolysis • vasodilation • intracellular transport • synaptic transmission, cholinergic • positive regulation of neuron death • high-density lipoprotein particle assembly • protein import • high-density lipoprotein particle remodeling • negative regulation of endothelial cell proliferation • maintenance of location in cell • negative regulation of platelet activation • low-density lipoprotein particle remodeling • positive regulation by host of viral process • cytoskeleton organization • regulation of neuron death • reverse cholesterol transport • lipoprotein catabolic process • triglyceride homeostasis • cellular oxidant detoxification • lipid transport involved in lipid storage Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	348	11816
Ensembl	ENSG00000130203	ENSMUSG00000002985
UniProt	P02649	P08226
RefSeq (mRNA)	NM_001302691 NM_000041 NM_001302688 NM_001302689 NM_001302690	NM_009696 NM_001305819 NM_001305843 NM_001305844
RefSeq (protein)	NP_000032 NP_001289617 NP_001289618 NP_001289619 NP_001289620	NP_001292748.1 NP_001292772.1 NP_001292773.1 NP_033826.2 NP_001292748 NP_001292772 NP_001292773 NP_033826
Location (UCSC)	Chr 19: 44.91 – 44.91 Mb	Chr 7: 19.7 – 19.7 Mb
PubMed search

1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B

348

11816

ENSG00000130203

ENSMUSG00000002985

P02649

P08226

NM_001302691
NM_000041
NM_001302688
NM_001302689
NM_001302690

...
Wikipedia