Apolipoprotein C1

APOC1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1ALE, 1ALF, 1IOJ, 1OPP
Identifiers
Aliases	APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1, Apolipoprotein C-I
External IDs	OMIM: 107710 HomoloGene: 136749 GeneCards: APOC1
Gene ontology Molecular function • phospholipase inhibitor activity • lipase inhibitor activity • phosphatidylcholine binding • fatty acid binding • phosphatidylcholine-sterol O-acyltransferase activator activity Cellular component • chylomicron • very-low-density lipoprotein particle • endoplasmic reticulum • high-density lipoprotein particle • extracellular exosome • extracellular region Biological process • lipid transport • chylomicron remnant clearance • negative regulation of fatty acid biosynthetic process • lipid metabolic process • positive regulation of cholesterol esterification • phospholipid efflux • cholesterol metabolic process • negative regulation of phosphatidylcholine catabolic process • plasma lipoprotein particle remodeling • negative regulation of very-low-density lipoprotein particle clearance • regulation of cholesterol transport • negative regulation of receptor-mediated endocytosis • high-density lipoprotein particle remodeling • Q22291617 • cholesterol efflux • negative regulation of cholesterol transport • negative regulation of lipoprotein lipase activity • very-low-density lipoprotein particle assembly • negative regulation of lipid catabolic process • triglyceride metabolic process • negative regulation of lipid metabolic process • positive regulation of catalytic activity • very-low-density lipoprotein particle clearance • lipoprotein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	341	n/a
Ensembl	ENSG00000130208	n/a
UniProt	P02654	n/a
RefSeq (mRNA)	NM_001645 NM_001321065 NM_001321066	n/a
RefSeq (protein)	NP_001307994 NP_001307995 NP_001636	n/a
Location (UCSC)	Chr 19: 44.91 – 44.92 Mb	n/a
PubMed search		n/a

ApoC-I
structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
Identifiers
Symbol	ApoC-I
Pfam	PF04691
InterPro	IPR006781
SCOP	1ale
SUPERFAMILY	1ale
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1ALE, 1ALF, 1IOJ, 1OPP

341

n/a

ENSG00000130208

n/a

P02654

n/a

NM_001645
NM_001321065
NM_001321066

n/a

NP_001307994
NP_001307995
NP_001636

n/a

Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene.

The protein encoded by this gene is a member of the apolipoprotein C family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within an apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.