Apolipoprotein C-II

APOC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SOH, 1BY6, 1I5J, 1O8T
Identifiers
Aliases	APOC2, APO-CII, APOC-II, apolipoprotein C2
External IDs	OMIM: 608083 MGI: 88054 HomoloGene: 47928 GeneCards: APOC2
Gene ontology Molecular function • lipase inhibitor activity • phospholipase binding • protein homodimerization activity • lipoprotein lipase activator activity • phospholipase activator activity • enzyme activator activity • lipid binding Cellular component • chylomicron • very-low-density lipoprotein particle • spherical high-density lipoprotein particle • extracellular region • early endosome • low-density lipoprotein particle • high-density lipoprotein particle • extracellular exosome • intermediate-density lipoprotein particle • extracellular space • cytosol Biological process • high-density lipoprotein particle clearance • lipoprotein metabolic process • lipid transport • positive regulation of triglyceride catabolic process • chylomicron remnant clearance • lipid metabolic process • phospholipid efflux • positive regulation of lipoprotein lipase activity • positive regulation of fatty acid biosynthetic process • negative regulation of very-low-density lipoprotein particle clearance • retinoid metabolic process • negative regulation of receptor-mediated endocytosis • lipid catabolic process • positive regulation of phospholipase activity • positive regulation of phospholipid catabolic process • cholesterol efflux • transport • chylomicron remodeling • very-low-density lipoprotein particle remodeling • negative regulation of cholesterol transport • cholesterol homeostasis • positive regulation of very-low-density lipoprotein particle remodeling • triglyceride-rich lipoprotein particle remodeling • triglyceride homeostasis • negative regulation of lipid metabolic process • reverse cholesterol transport • negative regulation of catalytic activity • response to drug • lipoprotein transport • positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	344	11813
Ensembl	ENSG00000224916	ENSMUSG00000002992
UniProt	P02655	Q05020
RefSeq (mRNA)	NM_000483	NM_001277944 NM_001309795
RefSeq (protein)	NP_000474 NP_000474.2	NP_001264873.1 NP_001296724.1 NP_001296728.1 NP_001296728 NP_001264873 NP_001296724
Location (UCSC)	Chr 19: 44.94 – 44.95 Mb	Chr 7: 19.67 – 19.68 Mb
PubMed search

Apo-CII
nmr structure of human apolipoprotein c-ii in the presence of sds
Identifiers
Symbol	Apo-CII
Pfam	PF05355
InterPro	IPR008019
SCOP	1by6
SUPERFAMILY	1by6
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1SOH, 1BY6, 1I5J, 1O8T

344

11813

ENSG00000224916

ENSMUSG00000002992

P02655

Q05020

NM_000483

NM_001277944
NM_001309795

NP_000474
NP_000474.2

NP_001296724

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons