Apaf-1

APAF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT

Identifiers

APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1

External IDs

MGI: 1306796 HomoloGene: 7626 GeneCards: APAF1

Gene ontology
Molecular function	• heat shock protein binding • ADP binding • protein binding • identical protein binding • ATP binding • nucleotide binding • cysteine-type endopeptidase activator activity involved in apoptotic process
Cellular component	• cytoplasm • cytosol • extracellular exosome • nucleus • apoptosome • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen
Biological process	• cellular response to transforming growth factor beta stimulus • neuron apoptotic process • regulation of apoptotic process • cell differentiation • response to hypoxia • response to nutrient • response to G1 DNA damage checkpoint signaling • aging • positive regulation of apoptotic signaling pathway • glial cell apoptotic process • nervous system development • multicellular organism development • cardiac muscle cell apoptotic process • intrinsic apoptotic signaling pathway • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • neural tube closure • brain development • positive regulation of apoptotic process • apoptotic signaling pathway • forebrain development • regulation of apoptotic DNA fragmentation • protein homooligomerization • activation of cysteine-type endopeptidase activity involved in apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • apoptotic process • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE APAF1 204859 s at tn.png

PBB GE APAF1 211553 x at tn.png

PBB GE APAF1 211554 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


317


11783


ENSG00000120868


ENSMUSG00000019979


O14727


O88879

RefSeq (mRNA)


NM_001160 NM_013229 NM_181861 NM_181868 NM_181869


NM_001042558 NM_001282947 NM_009684

RefSeq (protein)


NP_001151 NP_037361 NP_863651 NP_863658 NP_863659


NP_001036023.1 NP_033814.2 NP_001036023 NP_001269876 NP_033814

Location (UCSC)

Chr 12: 98.65 – 98.74 Mb

Chr 10: 90.99 – 91.08 Mb

PubMed search

1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT

ENSG00000120868

ENSMUSG00000019979

NM_001160
NM_013229
NM_181861
NM_181868
NM_181869

NM_001042558
NM_001282947
NM_009684

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Wikipedia

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