Annexin A1

ANXA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QLS, 1AIN, 1BO9
Identifiers
Aliases	ANXA1, ANX1, LPC1, annexin A1
External IDs	OMIM: 151690 MGI: 96819 HomoloGene: 563 GeneCards: ANXA1
Gene ontology Molecular function • calcium ion binding • protein binding, bridging • structural molecule activity • calcium-dependent protein binding • double-stranded DNA-dependent ATPase activity • receptor binding • phospholipid binding • annealing helicase activity • helicase activity • phospholipase A2 inhibitor activity • metal ion binding • protein homodimerization activity • single-stranded DNA binding • protein binding • calcium-dependent phospholipid binding • phospholipase inhibitor activity • single-stranded RNA binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • endosome • membrane • focal adhesion • extracellular region • nucleus • cell projection • mitochondrial membrane • cilium • cornified envelope • cell surface • extrinsic component of external side of plasma membrane • apical plasma membrane • motile cilium • extracellular exosome • early endosome membrane • lateral plasma membrane • plasma membrane • extrinsic component of endosome membrane • nucleoplasm • protein complex • early endosome • endosome membrane • extrinsic component of membrane • vesicle • mast cell granule • basolateral plasma membrane • sarcolemma • phagocytic cup • cytoplasmic vesicle membrane • cytoplasmic vesicle • cell-cell adherens junction • extracellular space • cytosol Biological process • response to interleukin-1 • adaptive immune response • estrous cycle • hepatocyte differentiation • prostate gland development • cell surface receptor signaling pathway • myoblast migration involved in skeletal muscle regeneration • granulocyte chemotaxis • endocrine pancreas development • gliogenesis • negative regulation of T-helper 2 cell differentiation • neutrophil homeostasis • prolactin secretion • positive regulation of wound healing • negative regulation of phospholipase A2 activity • negative regulation of interleukin-8 secretion • insulin secretion • regulation of leukocyte migration • positive regulation of G1/S transition of mitotic cell cycle • cellular response to glucocorticoid stimulus • positive regulation of T cell proliferation • phagocytosis • innate immune response • inflammatory response • arachidonic acid secretion • negative regulation of exocytosis • monocyte chemotaxis • immune system process • positive regulation of T-helper 1 cell differentiation • regulation of interleukin-1 production • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of apoptotic process • positive regulation of prostaglandin biosynthetic process • positive regulation of vesicle fusion • positive regulation of interleukin-2 production • regulation of inflammatory response • regulation of cell shape • alpha-beta T cell differentiation • response to hormone • actin cytoskeleton reorganization • response to estradiol • response to organic cyclic compound • response to peptide hormone • response to glucocorticoid • DNA strand renaturation • keratinocyte differentiation • positive regulation of neutrophil apoptotic process • DNA rewinding • response to corticosteroid • DNA duplex unwinding • peptide cross-linking • regulation of cell proliferation • neutrophil clearance • positive regulation of apoptotic process • regulation of hormone secretion • negative regulation of protein secretion • response to X-ray • response to drug • signal transduction • cellular response to hydrogen peroxide • cell-cell adhesion • negative regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	301	16952
Ensembl	ENSG00000135046	ENSMUSG00000024659
UniProt	P04083 Q5T3N0	P10107
RefSeq (mRNA)	NM_000700	NM_010730
RefSeq (protein)	NP_000691	NP_034860.2 NP_034860
Location (UCSC)	Chr 9: 73.15 – 73.17 Mb	Chr 19: 20.37 – 20.39 Mb
PubMed search

1QLS, 1AIN, 1BO9

301

16952

ENSG00000135046

ENSMUSG00000024659

P04083
Q5T3N0

P10107

NM_000700

NM_010730

NP_000691

NP_034860.2
NP_034860

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.

Annexin A1 belongs to the annexin family of Ca²⁺-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity.

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Wikipedia