Angiotensin II receptor type 2

AGTR2
Identifiers
Aliases	AGTR2, AT2, ATGR2, MRX88, Angiotensin II receptor type 2
External IDs	MGI: 87966 HomoloGene: 20172 GeneCards: AGTR2
Gene ontology Molecular function • signal transducer activity • receptor antagonist activity • peptide hormone binding • G-protein coupled receptor activity • transcription factor binding • protein binding • angiotensin type II receptor activity Cellular component • integral component of membrane • membrane • perinuclear region of cytoplasm • plasma membrane • integral component of plasma membrane • extracellular region Biological process • regulation of metanephros size • regulation of transcription factor import into nucleus • positive regulation of metanephric glomerulus development • intracellular signal transduction • kidney morphogenesis • regulation of apoptotic process • positive regulation of cytokine secretion • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of nitric-oxide synthase activity • signal transduction • dopamine biosynthetic process • positive regulation of nitric oxide biosynthetic process • negative regulation of norepinephrine secretion • cellular sodium ion homeostasis • renin-angiotensin regulation of aldosterone production • cellular response to dexamethasone stimulus • brain development • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • brain renin-angiotensin system • regulation of blood pressure • kidney development • negative regulation of icosanoid secretion • positive regulation of extrinsic apoptotic signaling pathway • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • aldosterone secretion • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • negative regulation of blood vessel endothelial cell migration • negative regulation of neurotrophin TRK receptor signaling pathway • response to organonitrogen compound • cerebellar cortex development • negative regulation of fibroblast proliferation • blood vessel remodeling • cell growth involved in cardiac muscle cell development • negative regulation of heart rate • negative regulation of cell growth • positive regulation of phosphoprotein phosphatase activity • exploration behavior • inflammatory response • positive regulation of renal sodium excretion • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • nitric oxide mediated signal transduction • angiotensin-activated signaling pathway • extracellular negative regulation of signal transduction • vasodilation • regulation of blood vessel diameter • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	186	11609
Ensembl	ENSG00000180772	ENSMUSG00000068122
UniProt	P50052	P35374
RefSeq (mRNA)	NM_000686	NM_007429
RefSeq (protein)	NP_000677	NP_031455.1 NP_031455
Location (UCSC)	Chr X: 116.17 – 116.17 Mb	Chr X: 21.48 – 21.49 Mb
PubMed search

186

11609

ENSG00000180772

ENSMUSG00000068122

P50052

P35374

NM_000686

NM_007429

NP_000677

NP_031455.1
NP_031455

Angiotensin II receptor type 2, also known as the AT₂ receptor is a protein that in humans is encoded by the AGTR2 gene.

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT₁ and AT₂. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.

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