Angiotensin I

AGT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FYS, 1N9U, 1N9V, 2JP8, 2WXW, 2X0B, 3CK0, 3WOO, 3WOR, 4AA1, 4APH, 5E2Q
Identifiers
Aliases	AGT, ANHU, SERPINA8, angiotensinogen
External IDs	MGI: 87963 HomoloGene: 14 GeneCards: AGT
Gene ontology Molecular function • type 1 angiotensin receptor binding • hormone activity • superoxide-generating NADPH oxidase activator activity • growth factor activity • type 2 angiotensin receptor binding • protein binding • sodium channel regulator activity • serine-type endopeptidase inhibitor activity • angiotensin receptor binding • receptor agonist activity Cellular component • cytoplasm • extracellular region • extracellular exosome • blood microparticle • extracellular space • cytosol Biological process • uterine smooth muscle contraction • renal system process • regulation of extracellular matrix assembly • vasoconstriction • positive regulation of cholesterol esterification • positive regulation of catalytic activity • positive regulation of cardiac muscle hypertrophy • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • cellular response to mechanical stimulus • blood vessel remodeling • positive regulation of reactive oxygen species metabolic process • stress-activated MAPK cascade • artery smooth muscle contraction • positive regulation of extrinsic apoptotic signaling pathway • regulation of systemic arterial blood pressure by renin-angiotensin • positive regulation of activation of JAK2 kinase activity • regulation of apoptotic process • positive regulation of cellular protein metabolic process • regulation of blood vessel size • negative regulation of neurotrophin TRK receptor signaling pathway • positive regulation of branching involved in ureteric bud morphogenesis • regulation of long-term neuronal synaptic plasticity • positive regulation of renal sodium excretion • kidney development • positive regulation of fibroblast proliferation • cellular sodium ion homeostasis • ERK1 and ERK2 cascade • activation of phospholipase C activity • angiotensin maturation • positive regulation of extracellular matrix constituent secretion • positive regulation of transcription, DNA-templated • positive regulation of blood pressure • negative regulation of cell growth • positive regulation of peptidyl-tyrosine phosphorylation • G-protein coupled receptor signaling pathway • regulation of norepinephrine secretion • positive regulation of inflammatory response • catenin import into nucleus • female pregnancy • positive regulation of protein tyrosine kinase activity • negative regulation of tissue remodeling • regulation of heart rate • regulation of blood pressure • positive regulation of macrophage derived foam cell differentiation • regulation of vasoconstriction • positive regulation of NF-kappaB transcription factor activity • positive regulation of NAD(P)H oxidase activity • nitric oxide mediated signal transduction • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • smooth muscle cell proliferation • positive regulation of epidermal growth factor receptor signaling pathway • regulation of blood volume by renin-angiotensin • regulation of cardiac conduction • regulation of calcium ion transport • regulation of transmission of nerve impulse • regulation of blood vessel diameter by renin-angiotensin • cell growth involved in cardiac muscle cell development • regulation of renal sodium excretion • positive regulation of cytokine production • positive regulation of membrane hyperpolarization • response to muscle activity involved in regulation of muscle adaptation • negative regulation of sodium ion transmembrane transporter activity • positive regulation of nitric oxide biosynthetic process • cytokine secretion • angiotensin-mediated drinking behavior • cell-cell signaling • renin-angiotensin regulation of aldosterone production • aging • vasodilation • positive regulation of endothelial cell migration • low-density lipoprotein particle remodeling • regulation of cell proliferation • regulation of cell growth • positive regulation of cell proliferation • fibroblast proliferation • negative regulation of angiogenesis • positive regulation of gap junction assembly • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of superoxide anion generation • positive regulation of L-arginine import into cell • positive regulation of L-lysine import into cell • positive regulation of glucose import in response to insulin stimulus • positive regulation of cardiac muscle cell apoptotic process • angiotensin-activated signaling pathway • positive regulation of vascular smooth muscle cell proliferation • positive regulation of cytosolic calcium ion concentration • negative regulation of gene expression • regulation of renal output by angiotensin • negative regulation of endopeptidase activity • positive regulation of vascular associated smooth muscle cell migration • regulation of molecular function Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	183	11606
Ensembl	ENSG00000135744	ENSMUSG00000031980
UniProt	P01019	P11859
RefSeq (mRNA)	NM_000029	NM_007428
RefSeq (protein)	NP_000020	n/a
Location (UCSC)	Chr 1: 230.7 – 230.71 Mb	Chr 8: 124.56 – 124.57 Mb
PubMed search

4FYS, 1N9U, 1N9V, 2JP8, 2WXW, 2X0B, 3CK0, 3WOO, 3WOR, 4AA1, 4APH, 5E2Q

183

11606

ENSG00000135744

ENSMUSG00000031980

P01019

P11859

NM_000029

NM_007428

NP_000020

n/a

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Aldosterone promotes sodium retention in the distal nephron, in the kidney, which also drives blood pressure up.

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