Angelo II Acciaioli (15 April 1349 - 31 May 1408) was an Italian Catholic cardinal.
Born in Florence, Angelo was elected Bishop of Rapolla in 1375, but in 1383 he was transferred to the see of Florence where he had been preceded by a previous family member many years before, Angelo Acciaioli. He was promoted to the cardinalate on 17 December 1384 by Pope Urban VI. He defended legality of the election of Urban VI and his successors against the claims of the antipopes Clement VII and Benedict XIII. In the Papal conclave, 1389 he was actively working on being elected to the papacy, but an anonymous narrative of the Conclave accuses him of simony (bribery), managing thereby to acquire six votes of the thirteen cardinals in the Conclave. Legate of Pope Boniface IX in the Kingdom of Naples in 1390 and in Hungary in 1403. He served as the Latin Archbishop of Patras, and hence ruler of a virtually independent domain in the northwestern Peloponnese, from 1395 to 1400.
Angelo crowned king Ladislaus of Naples. He reformed the Benedictine monastery S. Paolo fuori le mura in Rome and participated in the papal conclave, 1404. Newly elected Pope Innocent VII named him archpriest of the patriarchal Vatican Basilica (shortly after 4 December 1404), Cardinal-Bishop of Ostia e Velletri (12 June 1405), Dean of the Sacred College of Cardinals (12 June 1405), and finally Vice-Chancellor of the Holy Roman Church (on 29 August 1405). He presided over the papal conclave, 1406. He died in Pisa at the age of 59. His remains were transferred to the Carthusian monastery in Florence.