Anaplastic lymphoma kinase

ALK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4CLI, 4CLJ, 4CMO, 4CMT, 4CMU, 4CNH, 4CTB, 4CTC, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOD, 4JOA, 4MKC, 4TT7, 4Z55, 5FTO, 5AAB, 5AAA, 5J7H, 5AA9, 5IUH, 5IUI, 5IMX, 5FTQ, 5A9U, 5IUG, 5AA8, 5AAC
Identifiers
Aliases	ALK, CD246, NBLST3, Anaplastic lymphoma kinase, anaplastic lymphoma receptor tyrosine kinase, ALK receptor tyrosine kinase
External IDs	MGI: 103305 HomoloGene: 68387 GeneCards: ALK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • NF-kappaB-inducing kinase activity • protein binding • identical protein binding • ATP binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity Cellular component • integral component of membrane • membrane • protein complex • extracellular exosome • integral component of plasma membrane • intracellular • plasma membrane Biological process • regulation of apoptotic process • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • protein phosphorylation • positive regulation of NF-kappaB transcription factor activity • cell proliferation • protein autophosphorylation • activation of MAPK activity • signal transduction • neuron development • peptidyl-tyrosine phosphorylation • NIK/NF-kappaB signaling • phosphorylation • brain development • hippocampus development • adult behavior • swimming behavior • regulation of cell proliferation • regulation of dopamine receptor signaling pathway • response to environmental enrichment Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	238	11682
Ensembl	ENSG00000171094	ENSMUSG00000055471
UniProt	Q9UM73	P97793
RefSeq (mRNA)	NM_004304	NM_007439
RefSeq (protein)	NP_004295	NP_031465.2 NP_031465
Location (UCSC)	Chr 2: 29.19 – 29.92 Mb	Chr 17: 71.87 – 72.6 Mb
PubMed search

2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4CLI, 4CLJ, 4CMO, 4CMT, 4CMU, 4CNH, 4CTB, 4CTC, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOD, 4JOA, 4MKC, 4TT7, 4Z55, 5FTO, 5AAB, 5AAA, 5J7H, 5AA9, 5IUH, 5IUI, 5IMX, 5FTQ, 5A9U, 5IUG, 5AA8, 5AAC

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