Aminopeptidase N

ANPEP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FYQ, 4FYR, 4FYS, 4FYT
Identifiers
Aliases	ANPEP, APN, CD13, GP150, LAP1, P150, PEPN, alanyl aminopeptidase, membrane
External IDs	OMIM: 151530 MGI: 5000466 HomoloGene: 68163 GeneCards: ANPEP
Gene location (Human) Chr. Chromosome 15 (human) Band n/a Start 89,784,889 bp End 89,815,401 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band n/a Start 79,821,803 bp End 79,861,059 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • virus receptor activity • zinc ion binding • receptor activity • metalloaminopeptidase activity • hydrolase activity • metal ion binding • peptidase activity • aminopeptidase activity • metallopeptidase activity • peptide binding Cellular component • lysosomal membrane • integral component of membrane • membrane • endoplasmic reticulum-Golgi intermediate compartment • external side of plasma membrane • extracellular exosome • extracellular space • nucleus • plasma • secretory granule membrane Biological process • viral process • peptide catabolic process • proteolysis • viral entry into host cell • multicellular organism development • cell differentiation • angiogenesis • neutrophil degranulation • signal transduction • cell-cell signaling • regulation of blood pressure Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	290	16790
Ensembl	ENSG00000166825	ENSMUSG00000039062
UniProt	P15144	P97449
RefSeq (mRNA)	NM_001150	NM_008486
RefSeq (protein)	NP_001141	NP_032512
Location (UCSC)	Chr 15: 89.78 – 89.82 Mb	Chr 15: 79.82 – 79.86 Mb
PubMed search

4FYQ, 4FYR, 4FYS, 4FYT

290

16790

ENSG00000166825

ENSMUSG00000039062

P15144

P97449

NM_001150

NM_008486

NP_001141

NP_032512

Membrane alanyl aminopeptidase (EC 3.4.11.2) also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene.

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

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