Amidrine

Amidrine, Duradrin, Epidrine, Nodolor or Midrin, is a combination of acetaminophen, dichloralphenazone, and isometheptene used mostly to treat headaches.

The pathophysiology of vascular headaches, especially migraine, is thought to be related to dilation of these cerebral blood vessels, so drugs that act to constrict them are used in the treatment of these problems.

This drug is commonly used in the treatment of migraine headaches and is currently available in the United States and United Kingdom by prescription only.

One study has shown that this drug may work better than Imitrex for treating migraines.

Midrin was discontinued by Caraco Pharmaceuticals as of 2009 after an FDA seizure of 33 drugs manufactured by Caraco Pharmaceuticals due to cGMP (Current Good Manufacturing Practices) violations. Generic forms of midrine were also discontinued due to loss of FDA grandfather approval status. Manufacturers felt it was not financially prudent to perform FDA testing. The discontinued generic forms are: Amidrine (Actavis), Duradrin (Barr), I.D.A (Teva), Migquin (Qualitest), Migrin-A (Prasco)and Migrazone (Breckenridge). However, it is being manufactured again by Macoven Pharmaceuticals and marketed under the name Nodolor as of April, 2014. It can also be obtained through a compounding pharmacy with a doctor's prescription.

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