Amidation

An amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/), also known as an acid amide, is a compound with the functional group R_nE(O)_xNR′₂ (R and R′ refer to H or organic groups). Most common are carboxamides (organic amides) (n = 1, E = C, x = 1), but many other important types of amides are known, including phosphoramides (n = 2, E = P, x = 1 and many related formulas) and sulfonamides (E = S, x = 2). The term amide refers both to classes of compounds and to the functional group (R_nE(O)_xNR′₂) within those compounds.

Amide can also refer to the conjugate base of ammonia (the anion H₂N⁻) or of an organic amine (an anion R₂N⁻). For discussion of these "anionic amides", see Alkali metal amides.

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