Ameloblastin

AMBN
Identifiers
Aliases	AMBN, AI1F, ameloblastin
External IDs	MGI: 104655 HomoloGene: 7625 GeneCards: AMBN
Gene ontology Molecular function • structural constituent of tooth enamel • growth factor activity • protein binding Cellular component • proteinaceous extracellular matrix • extracellular region • endoplasmic reticulum lumen Biological process • odontogenesis of dentin-containing tooth • biomineral tissue development • cell adhesion • cell proliferation • post-translational protein modification • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	258	11698
Ensembl	ENSG00000178522	ENSMUSG00000029288
UniProt	Q9NP70	O55189
RefSeq (mRNA)	NM_016519	NM_009664 NM_001303431
RefSeq (protein)	NP_057603	NP_001290360 NP_033794
Location (UCSC)	Chr 4: 70.59 – 70.61 Mb	Chr 5: 88.46 – 88.47 Mb
PubMed search

258

11698

ENSG00000178522

ENSMUSG00000029288

Q9NP70

O55189

NM_016519

NM_009664
NM_001303431

NP_057603

NP_001290360
NP_033794

Ameloblastin (enamel matrix protein) is a protein that in humans is encoded by the AMBN gene.

Ameloblastin, also known as amelin, is a gene-specific protein found in tooth enamel. Although less than 5% of enamel consists of protein, ameloblastins comprise 5%-10% of all enamel protein. This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not completely understood, the function of ameloblastins is believed to be in controlling the elongation of enamel crystals and generally directing enamel mineralization during tooth development.

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Wikipedia