Alpha 2-macroglobulin

Alpha-2-Macroglobulin

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4ACQ, 2P9R, 1BV8

Identifiers

A2M, A2MD, CPAMD5, FWP007, S863-7, transcuprein

External IDs

Gene ontology
Molecular function	• peptidase inhibitor activity • interleukin-8 binding • growth factor binding • calcium-dependent protein binding • protease binding • protein binding • serine-type endopeptidase inhibitor activity • enzyme binding • tumor necrosis factor binding • endopeptidase inhibitor activity • interleukin-1 binding • receptor binding • GTPase activator activity
Cellular component	• cytosol • blood microparticle • extracellular region • extracellular exosome • platelet alpha granule lumen • extracellular space
Biological process	• blood coagulation, intrinsic pathway • negative regulation of peptidase activity • platelet degranulation • extracellular matrix disassembly • stem cell differentiation • negative regulation of complement activation, lectin pathway • regulation of small GTPase mediated signal transduction • positive regulation of GTPase activity • negative regulation of endopeptidase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2


232345


ENSG00000175899


ENSMUSG00000030111


P01023


Q6GQT1

RefSeq (mRNA)


NM_000014


NM_175628

RefSeq (protein)


NP_000005 NP_001334352 NP_001334353 NP_001334354


NP_783327.2 NP_783327

Location (UCSC)

PubMed search

alpha-2-Macroglobulin (α2M) is a large plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. In humans it is encoded by the A2M gene.