Alpha 2-antiplasmin

SERPINF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R9Y
Identifiers
Aliases	SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI, serpin family F member 2
External IDs	OMIM: 613168 MGI: 107173 HomoloGene: 719 GeneCards: SERPINF2
Gene ontology Molecular function • peptidase inhibitor activity • protein homodimerization activity • protease binding • protein binding • serine-type endopeptidase inhibitor activity • endopeptidase inhibitor activity Cellular component • blood microparticle • fibrinogen complex • extracellular region • cell surface • extracellular exosome • platelet alpha granule lumen • extracellular space Biological process • positive regulation of collagen biosynthetic process • negative regulation of peptidase activity • negative regulation of fibrinolysis • negative regulation of plasminogen activation • regulation of blood vessel diameter by renin-angiotensin • blood vessel morphogenesis • fibrinolysis • collagen fibril organization • platelet degranulation • positive regulation of JNK cascade • response to organic substance • acute-phase response • positive regulation of cell differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of transforming growth factor beta production • positive regulation of stress fiber assembly • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • positive regulation of cell-cell adhesion mediated by cadherin • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5345	18816
Ensembl	n/a	ENSMUSG00000038224
UniProt	P08697	Q61247
RefSeq (mRNA)	NM_000934 NM_001165920 NM_001165921	NM_008878
RefSeq (protein)	NP_000925 NP_001159392 NP_001159393	NP_032904.1
Location (UCSC)	Chr 17: 1.74 – 1.76 Mb	Chr 11: 75.43 – 75.44 Mb
PubMed search

2R9Y

5345

18816

n/a

ENSMUSG00000038224

P08697

Q61247

NM_000934
NM_001165920
NM_001165921

NM_008878

NP_000925
NP_001159392
NP_001159393

NP_032904.1

Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

...
Wikipedia