Alp Ikizler

T. Alp Ikizler is a nephrologist, currently holding the Catherine McLaughlin Hakim chair in Medicine at Vanderbilt University School of Medicine, where he does clinical work and heads a research lab. Born in Istanbul, Turkey, he received his M.D. from the Istanbul University Faculty of Medicine.

Dr. Ikizler's research focuses on the nutritional and metabolic aspects of kidney disease. Specifically, his work involves identifying reliable and practical tests for protein-caloric malnutrition, which is associated with heightened risks of mortality in renal failure patients, and using these tests to assess different treatment strategies. One study established that dialysis changes protein metabolism in such a way as to stimulate protein degradation in muscle and other tissues. Work by Ikizler's team showed that dialysis-stimulated proteolysis is partly induced by inflammation; and that parenteral nutrition during dialysis, as well as exercise during dialysis, can mitigate the defects in protein metabolism. Later papers assessed the effectiveness of oral nutritional supplementation, alone or with resistance exercise.

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