Aldosterone synthase

CYP11B2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4DVQ, 4FDH, 4ZGX
Identifiers
Aliases	CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 family 11 subfamily B member 2
External IDs	MGI: 88583 HomoloGene: 106948 GeneCards: CYP11B2
EC number	1.14.15.4
Targeted by Drug
fadrozole
Gene ontology Molecular function • iron ion binding • corticosterone 18-monooxygenase activity • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • steroid 11-beta-monooxygenase activity • steroid hydroxylase activity Cellular component • mitochondrial membrane • membrane • mitochondrion • mitochondrial inner membrane Biological process • lipid metabolic process • aldosterone biosynthetic process • cortisol biosynthetic process • C21-steroid hormone biosynthetic process • cellular response to hormone stimulus • potassium ion homeostasis • mineralocorticoid biosynthetic process • regulation of blood volume by renal aldosterone • renal water homeostasis • sterol metabolic process • sodium ion homeostasis • oxidation-reduction process • cellular response to potassium ion • steroid biosynthetic process • steroid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1585	110115
Ensembl	ENSG00000179142	ENSMUSG00000075604
UniProt	P19099	n/a
RefSeq (mRNA)	NM_000498	NM_001033229
RefSeq (protein)	NP_000489	n/a
Location (UCSC)	Chr 8: 142.91 – 142.92 Mb	Chr 15: 74.83 – 74.84 Mb
PubMed search

4DVQ, 4FDH, 4ZGX

1585

110115

ENSG00000179142

ENSMUSG00000075604

P19099

n/a

NM_000498

NM_001033229

NP_000489

n/a

Aldosterone synthase is a steroid hydroxylase enzyme involved in the biosynthesis of the mineralocorticoid aldosterone. It is a protein which is only expressed in the zona glomerulosa of the adrenal cortex and is primarily regulated by the renin-angiotensin system. It is the sole enzyme capable of synthesizing aldosterone in humans and plays an important role in electrolyte balance and blood pressure.

Aldosterone synthase is encoded on chromosome 8q22 by the CYP11B2 gene. The gene contains 9 exons and spans roughly 7000 base pairs of DNA. CYP11B2 is closely related with CYP11B1. The two genes show 93% homology to each other and are both encoded on the same chromosome. Research has shown that calcium ions act as a transcription factor for CYP11B2 through well defined interactions at the 5'-flanking region of CYP11B2.

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Wikipedia