Aldehyde oxidase 1

AOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UHW, 4UHX, 5EPG
Identifiers
Aliases	AOX1, AO, AOH1, aldehyde oxidase 1
External IDs	MGI: 88035 HomoloGene: 68165 GeneCards: AOX1
Gene ontology Molecular function • iron ion binding • aldehyde oxidase activity • flavin adenine dinucleotide binding • oxidoreductase activity, acting on CH-OH group of donors • iron-sulfur cluster binding • NAD binding • metal ion binding • catalytic activity • molybdopterin cofactor binding • electron carrier activity • xanthine dehydrogenase activity • oxidoreductase activity • 2 iron, 2 sulfur cluster binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors Cellular component • extracellular exosome • cytoplasm • cytosol • nuclear body Biological process • reactive oxygen species metabolic process • xanthine catabolic process • inflammatory response • vitamin B6 metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	316	11761
Ensembl	ENSG00000138356	ENSMUSG00000063558
UniProt	Q06278	O54754
RefSeq (mRNA)	NM_001159	NM_009676
RefSeq (protein)	NP_001150	NP_033806.2 NP_033806
Location (UCSC)	Chr 2: 200.59 – 200.68 Mb	Chr 1: 58.03 – 58.11 Mb
PubMed search

4UHW, 4UHX, 5EPG

316

11761

ENSG00000138356

ENSMUSG00000063558

Q06278

O54754

NM_001159

NM_009676

NP_001150

NP_033806.2
NP_033806

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.

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Wikipedia