Husayni (Arabic: الحسيني also spelled Husseini) is the name of a prominent Palestinian Arab clan formerly based in Jerusalem, which claims descent from Husayn ibn Ali (the son of Ali).
The Husaynis follow the Hanafi school of Sunni Islam, in contrast to the Shafi school followed by most of the Arab Muslim population of Palestine.
The Husaynis migrated to Jerusalem in the 12th century after Saladin drove out the Crusaders from the city and much of the Levant.
The Husaynis were a major force in rebelling against Muhammad Ali who governed Egypt and Palestine in defiance of the Ottoman Empire. This solidified a cooperative relationship with the returning Ottoman authority. The clan took part in fighting the Qaisi tribe in an alliance with a rural lord of the Jerusalem area Mustafa Abu Ghosh, who clashed with the tribe frequently. The feuds gradually occurred in the city between the clan and the Khalidis that led the Qaisis, however these conflicts dealt with city positions and not Qaisi-Yamani rivalry. The Husaynis later led opposition and propaganda movements against the Young Turks who controlled the Ottoman Empire.
By the time of the British Mandate the clan had hundreds of members and its several branches encompassed thousands. They were mostly concentrated in the Old City, however a large number of clan members also lived in the neighborhoods of Sheikh Jarrah, the German Colony, Katamon, Baka and Musrara. Several members of the clan were appointed to important political positions such as Mayor and Grand Mufti of Jerusalem. Musa al-Husayni was mayor of Jerusalem, 1918–1920. Mohammed Tahir al-Husayni was Grand Mufti of Jerusalem, 1860s-1908, followed by his son Kamil al-Husayni, 1908-1921, and then another son Mohammad Amin al-Husayni, 1921-1937. The main political rivals for the clan was the Nashashibi clan of Jerusalem, especially during the Mandate period. Before the formal commencement of the British Mandate, Musa and Amin al-Husayni incited the 1920 Palestine riots, resulting in many deaths. As a result, Musa was replaced as mayor by the head of the rival Nashashibi clan.Amin al-Husayni and Aref al-Aref were arrested, but when they were let out on bail they both escaped to Syria. A military court sentenced Amin in absentia to 10 years imprisonment, and he failed to qualify for a general amnesty in early 1921 because of his absence.