Adrenodoxin reductase

FDXR
Identifiers
Aliases	FDXR, ADXR, Adrenodoxin reductase, ferredoxin reductase
External IDs	MGI: 104724 HomoloGene: 3033 GeneCards: FDXR
Gene ontology Molecular function • oxidoreductase activity • ferredoxin-NADP+ reductase activity • protein binding • NADPH-adrenodoxin reductase activity Cellular component • mitochondrial matrix • mitochondrion Biological process • C21-steroid hormone biosynthetic process • sterol metabolic process • cholesterol metabolic process • oxidation-reduction process • generation of precursor metabolites and energy • steroid biosynthetic process • lipid metabolic process • steroid metabolic process • ubiquinone biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2232	14149
Ensembl	ENSG00000161513	ENSMUSG00000018861
UniProt	P22570	Q61578
RefSeq (mRNA)	NM_001258012 NM_001258013 NM_001258014 NM_001258015 NM_001258016 NM_004110 NM_024417	NM_007997
RefSeq (protein)	NP_001244941 NP_001244942 NP_001244943 NP_001244944 NP_001244945 NP_004101 NP_077728	NP_032023
Location (UCSC)	Chr 17: 74.86 – 74.87 Mb	Chr 11: 115.27 – 115.28 Mb
PubMed search

2232

14149

ENSG00000161513

ENSMUSG00000018861

P22570

Q61578

NM_004110
NM_024417

NM_007997

NP_004101
NP_077728

NP_032023

NADPH:adrenodoxin oxidoreductase, mitochondrial also known as adrenodoxin reductase is an enzyme that in humans is encoded by the FDXR gene, also known as ADXR. It catalyzes the following reaction:

ADXR gene is expressed in all tissues that have mitochondrial P450s. The highest levels of the enzyme is found in the adrenal cortex, granulosa cells of the ovary and leydig cells of the testis that specialize in steroid hormone synthesis. In addition the enzyme is also expressed in the liver, the kidney and the placenta.

The cDNA for adrenodoxin reductase was first cloned in 1987. In both bovine and human genomes there is only a single copy of the gene.

Adrenodoxin reductase is an FAD containing flavoprotein that accepts two electrons from NADPH. The FAD and NADP binding sites of the enzyme were predicted by sequence analysis of the enzyme. The location of these FAD and NADP binding sites were confirmed by the crystal structure of the FAD bound enzyme in 1999.

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Wikipedia