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Trade names | Acortan, Acthar, Acton, Cortigel, Trofocortina |
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ECHA InfoCard | 100.037.286 |
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Formula | C207H308N56O58S |
Molar mass | 4541.135 g/mol |
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Trade names | Cortrosyn, Synacthen, Nuvacthen |
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Synonyms | Ba 30920 α1–24 corticotrophin Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro |
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ChEBI | |
ECHA InfoCard | 100.037.286 |
Chemical and physical data | |
Formula | C136H210N40O31S |
Molar mass | 2933.44 g/mol |
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(what is this?) |
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test.
The form that is purified from pig pituitary glands is known as corticotropin (INN, BAN) is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland.
The form that is made synthetically is tetracosactide (INN), also known as tetracosactrin (BAN) and cosyntropin (USAN), and the acetate ester, tetracosactide acetate (JAN), also known as tetracosactrin acetate (BANM). It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide. Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.
Both corticotropin and tetracosactide have been used for diagnostic purposes to determine adrenocortical insufficiency, particularly in Addison's disease, via the ACTH stimulation test. However, as of 2015 the US label for corticotropin does not include diagnostic use.