Adrenocorticotropic hormone (medication)

Adrenocorticotropic hormone (medication)
Clinical data
Trade names	Acortan, Acthar, Acton, Cortigel, Trofocortina
AHFS/Drugs.com	International Drug Names
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
PubChem CID	16132265
ECHA InfoCard	100.037.286
Chemical and physical data
Formula	C₂₀₇H₃₀₈N₅₆O₅₈S
Molar mass	4541.135 g/mol

Adrenocorticotropic hormone (medication)
Clinical data

Trade names	Cortrosyn, Synacthen, Nuvacthen
AHFS/Drugs.com	International Drug Names
ATC code	H01AA02 (WHO)
Identifiers
IUPAC name L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
Synonyms	Ba 30920 α^1–24 corticotrophin Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
CAS Number	16960-16-0^Y
PubChem CID	16129617
IUPHAR/BPS	6965
DrugBank	DB01284^N
ChemSpider	10481947^Y
UNII	72YY86EA29
KEGG	D00284^Y
ChEBI	CHEBI:3901^Y
ECHA InfoCard	100.037.286
Chemical and physical data
Formula	C₁₃₆H₂₁₀N₄₀O₃₁S
Molar mass	2933.44 g/mol
InChI InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86?,88-,89-,90+,91-,92+,93+,94+,95+,96-,97+,98+,99+,100+,101+,102+,103+,104+,105+,109+,110+,111+/m1/s1^N Key:ZOEFCCMDUURGSE-CQVUSSRSSA-N^N
^NY (what is this?)

Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test.

The form that is purified from pig pituitary glands is known as corticotropin (INN, BAN) is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland.

The form that is made synthetically is tetracosactide (INN), also known as tetracosactrin (BAN) and cosyntropin (USAN), and the acetate ester, tetracosactide acetate (JAN), also known as tetracosactrin acetate (BANM). It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide. Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.

Both corticotropin and tetracosactide have been used for diagnostic purposes to determine adrenocortical insufficiency, particularly in Addison's disease, via the ACTH stimulation test. However, as of 2015 the US label for corticotropin does not include diagnostic use.

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