Adipose triglyceride lipase

PNPLA2
Identifiers
Aliases	PNPLA2, 1110001C14Rik, ATGL, PEDF-R, TTS-2.2, TTS2, iPLA2zeta, FP17548, patatin like phospholipase domain containing 2
External IDs	MGI: 1914103 HomoloGene: 10687 GeneCards: PNPLA2
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 818,902 bp End 825,573 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F5 Start 141,455,198 bp End 141,460,743 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrolase activity • lipoprotein lipase activity • acylglycerol O-acyltransferase activity • triglyceride lipase activity Cellular component • integral component of membrane • cytosol • lipid droplet • plasma membrane • endoplasmic reticulum membrane • cytoplasm • membrane • nucleoplasm • endoplasmic reticulum lumen Biological process • lipid catabolic process • lipid storage • metabolism • negative regulation of sequestering of triglyceride • positive regulation of triglyceride catabolic process • acylglycerol acyl-chain remodeling • lipid particle organization • lipid metabolic process • triglyceride catabolic process • lipid homeostasis • post-translational protein modification • cellular protein metabolic process • cellular lipid catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57104	66853
Ensembl	ENSG00000177666	ENSMUSG00000025509
UniProt	Q96AD5	Q8BJ56
RefSeq (mRNA)	NM_020376	NM_001163689 NM_025802
RefSeq (protein)	NP_065109	NP_001157161 NP_080078
Location (UCSC)	Chr 11: 0.82 – 0.83 Mb	Chr 11: 141.46 – 141.46 Mb
PubMed search

57104

66853

ENSG00000177666

ENSMUSG00000025509

Q96AD5

Q8BJ56

NM_020376

NM_001163689
NM_025802

NP_065109

NP_001157161
NP_080078

Adipose triglyceride lipase also known as patatin-like phospholipase domain-containing protein 2 is an enzyme that in humans is encoded by the PNPLA2 gene.

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Wikipedia