Adiponectin receptor 2

ADIPOR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WXW
Identifiers
Aliases	ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs	MGI: 93830 HomoloGene: 56119 GeneCards: ADIPOR2
Gene ontology Molecular function • adipokinetic hormone receptor activity • adiponectin binding • metal ion binding • identical protein binding • protein heterodimerization activity • receptor activity Cellular component • integral component of membrane • membrane • intrinsic component of plasma membrane • plasma membrane Biological process • positive regulation of glucose import • glucose homeostasis • response to nutrient • lipid metabolic process • female pregnancy • adiponectin-activated signaling pathway • fatty acid metabolic process • vascular wound healing • heart development • negative regulation of cell growth • fatty acid oxidation • hormone-mediated signaling pathway • G-protein coupled receptor signaling pathway • regulation of fatty acid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79602	68465
Ensembl	ENSG00000006831	ENSMUSG00000030168
UniProt	Q86V24	Q8BQS5
RefSeq (mRNA)	NM_024551	NM_197985
RefSeq (protein)	NP_078827	NP_932102.2 NP_932102
Location (UCSC)	Chr 12: 1.69 – 1.79 Mb	Chr 6: 119.35 – 119.42 Mb
PubMed search

3WXW

79602

68465

ENSG00000006831

ENSMUSG00000030168

Q86V24

Q8BQS5

NM_024551

NM_197985

NP_078827

NP_932102.2
NP_932102

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.

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