Adenylosuccinate lyase

ADSL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2J91, 2VD6, 4FFX, 4FLC

Identifiers

Aliases

ADSL, AMPS, ASASE, ASL, adenylosuccinate lyase

External IDs

OMIM: 608222 MGI: 103202 HomoloGene: 12 GeneCards: ADSL

Gene ontology
Molecular function	• N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity • (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity • catalytic activity • lyase activity
Cellular component	• cytosol • mitochondrion
Biological process	• purine nucleotide biosynthetic process • response to hypoxia • purine ribonucleotide biosynthetic process • 'de novo' IMP biosynthetic process • response to nutrient • protein tetramerization • ribonucleoside monophosphate biosynthetic process • aerobic respiration • purine ribonucleoside monophosphate biosynthetic process • response to starvation • purine nucleotide metabolic process • AMP biosynthetic process • response to muscle activity • 'de novo' AMP biosynthetic process • metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


158


11564

Ensembl


ENSG00000239900


ENSMUSG00000022407

UniProt


P30566


P54822

RefSeq (mRNA)


NM_000026 NM_001123378 NM_001317923


NM_009634

RefSeq (protein)


NP_000017 NP_001116850 NP_001304852


NP_033764.2 NP_033764

Location (UCSC)

Chr 22: 40.35 – 40.39 Mb

Chr 15: 80.95 – 80.97 Mb

PubMed search

Adenylosuccinate lyase

'The homotetrameric structure of ASL in Thermotoga maritima Domain 1 is in red, Domain 2 is in blue, Domain 3 is in yellow. This structure was inspired by a paper by Toth and Yeates

Identifiers

Databases