Adenosine deaminase

ADA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IAR
Identifiers
Aliases	ADA, entrez:100, Adenosine deaminase
External IDs	OMIM: 608958 MGI: 87916 HomoloGene: 37249 GeneCards: ADA
Targeted by Drug
pentostatin
Gene ontology Molecular function • deaminase activity • zinc ion binding • metal ion binding • hydrolase activity • purine nucleoside binding • protein binding • adenosine deaminase activity Cellular component • membrane • cytoplasmic vesicle lumen • cell surface • cell junction • neuronal cell body • dendrite cytoplasm • cytoplasmic vesicle • external side of plasma membrane • extracellular space • cytoplasm • lysosome • plasma membrane • cytosol Biological process • positive regulation of T cell differentiation • histamine secretion • negative regulation of circadian sleep/wake cycle, non-REM sleep • purine nucleotide salvage • positive regulation of T cell differentiation in thymus • positive regulation of calcium-mediated signaling • xanthine biosynthetic process • response to hypoxia • lung development • placenta development • deoxyadenosine catabolic process • positive regulation of T cell receptor signaling pathway • adenosine metabolic process • purine-containing compound salvage • dATP catabolic process • aging • negative regulation of thymocyte apoptotic process • negative regulation of apoptotic process • in utero embryonic development • negative regulation of mature B cell apoptotic process • nucleotide metabolic process • response to vitamin E • positive regulation of heart rate • negative regulation of adenosine receptor signaling pathway • response to morphine • regulation of cell-cell adhesion mediated by integrin • T cell activation • cell adhesion • positive regulation of T cell activation • positive regulation of B cell proliferation • trophectodermal cell differentiation • regulation of circadian sleep/wake cycle, sleep • hypoxanthine biosynthetic process • purine ribonucleoside monophosphate biosynthetic process • germinal center B cell differentiation • liver development • lung alveolus development • Peyer's patch development • negative regulation of mucus secretion • inosine biosynthetic process • positive regulation of smooth muscle contraction • negative regulation of inflammatory response • negative regulation of leukocyte migration • positive regulation of germinal center formation • positive regulation of alpha-beta T cell differentiation • embryonic digestive tract development • negative regulation of penile erection • response to drug • regulation of T cell differentiation • response to hydrogen peroxide • adenosine catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	100	11486
Ensembl	ENSG00000196839	ENSMUSG00000017697
UniProt	P00813	P03958
RefSeq (mRNA)	NM_000022 NM_001322050 NM_001322051	NM_001272052 NM_007398
RefSeq (protein)	NP_000013 NP_001308979 NP_001308980	NP_001258981.1 NP_031424.1 NP_001258981 NP_031424
Location (UCSC)	Chr 20: 44.62 – 44.65 Mb	Chr 2: 163.73 – 163.75 Mb
PubMed search

Adenosine/AMP deaminase
crystal structure of plasmodium yoelii adenosine deaminase (py02076)
Identifiers
Symbol	A_deaminase
Pfam	PF00962
Pfam clan	CL0034
InterPro	IPR001365
PROSITE	PDOC00419
SCOP	1add
SUPERFAMILY	1add
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

3IAR

100

11486

ENSG00000196839

ENSMUSG00000017697

P00813

P03958

NM_000022
NM_001322050
NM_001322051

NM_001272052
NM_007398

NP_000013
NP_001308979
NP_001308980

NP_001258981.1
NP_031424.1
NP_001258981
NP_031424

Adenosine Deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.