Adenosine A2B receptor

ADORA2B
Identifiers
Aliases	ADORA2B, ADORA2, adenosine A2b receptor
External IDs	MGI: 99403 HomoloGene: 20167 GeneCards: ADORA2B
Gene ontology Molecular function • G-protein coupled adenosine receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intracellular Biological process • cellular response to extracellular stimulus • cellular protein metabolic process • positive regulation of chronic inflammatory response to non-antigenic stimulus • G-protein coupled receptor signaling pathway • positive regulation of cAMP biosynthetic process • adenosine receptor signaling pathway • excretion • positive regulation of guanylate cyclase activity • adenylate cyclase-activating G-protein coupled receptor signaling pathway • positive regulation of cGMP biosynthetic process • positive regulation of mast cell degranulation • activation of adenylate cyclase activity • cellular defense response • JNK cascade • activation of MAPK activity • positive regulation of interleukin-6 production • relaxation of vascular smooth muscle • positive regulation of chemokine production • positive regulation of vascular endothelial growth factor production • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	136	11541
Ensembl	ENSG00000170425	ENSMUSG00000018500
UniProt	P29275	Q60614
RefSeq (mRNA)	NM_000676	NM_007413
RefSeq (protein)	NP_000667	NP_031439
Location (UCSC)	Chr 17: 15.94 – 15.98 Mb	Chr 11: 62.25 – 62.27 Mb
PubMed search

136

11541

ENSG00000170425

ENSMUSG00000018500

P29275

Q60614

NM_000676

NM_007413

NP_000667

NP_031439

The adenosine A_2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A_2b receptor gene which encodes it.

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

The gene is located near the Smith-Magenis syndrome region on chromosome 17.

Research into selective A_2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A_2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing.

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