Gene ontology
Molecular function	• methyltransferase activity • transferase activity • S-adenosylmethionine-dependent methyltransferase activity • protein homodimerization activity • O-methyltransferase activity • acetylserotonin O-methyltransferase activity • identical protein binding • S-methyltransferase activity
Cellular component	• cytosol
Biological process	• melatonin biosynthetic process • methylation • translation • indolalkylamine biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


438


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Ensembl


ENSG00000196433


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UniProt


P46597


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RefSeq (mRNA)


NM_004043 NM_001171038 NM_001171039


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RefSeq (protein)


NP_001164509 NP_001164510 NP_004034


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Location (UCSC)

Chr X: 1.62 – 1.64 Mb

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PubMed search

n/a

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NM_004043
NM_001171038
NM_001171039

n/a

NP_001164509
NP_001164510
NP_004034

n/a

N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.

In humans the ASMT enzyme is encoded by the ASMT gene. There are two identical copies, one of which resides on the X chromosome and the other on the Y chromosome.

N-Acetylserotonin O-methyltransferase is an enzyme that is coded for by genes located on the pseudoautosomal region of the X and Y chromosome, and is most abundantly found in the pineal gland and retina of humans. Although the exact structure of N- Acetylserotonin O-methyltransferase has yet to be determined by X-Ray diffraction, the crystal structure of the Maf domain of human N-Acetylserotonin O-methyltransferase-like protein has been found.

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Wikipedia