Condat Abbey was founded in the 420s in the valley of Bienne, in the Jura mountains, in modern-day France. Condat became the capital of Haut Jura. The founders were local monks, Romanus (died c. 463), who had been ordained by St. Hilary of Arles in 444, and his younger brother Lupicinus of Lyon (Lupicin); the easily defended isolated site they chose for the separate cells in which they and their followers would live in emulation of the Eastern manner of the Desert Fathers was on a stony headland at the confluence of the rivers Bienne and Tacon. Though the site still contained Roman ruins, it was accounted a 'desert' in the Life of the Fathers of the Jura, which contains the early saint's lives. Romanus continued founding other abbeys, such as Romainmôtier Abbey at Romainmôtier-Envy, which retains his name. Not far away at La Balme, Yole, the sister of Romanus and Lupicinus, founded her nunnery.
The establishment at Condat developed into one of the pre-eminent monasteries of the Merovingian and Carolingian eras. The fourth abbot, Eugendus (Oyend, died c. 510–515), was educated in the monastery and never left it. As abbot he rebuilt it in stone and transformed its early eremitism to a coenobitic rule. Oyend increased the independence of the monastery and transformed it into an ecclesiastical principality that ruled all Upper Jura; nevertheless, the diplomas apparently from Charlemagne and confirming territorial rights were demonstrated by René Poupardin to be forgeries, apparently of the eleventh century. After the time of Oyend, the monastery at Condat and the village that developed around its protective walls were known as Saint-Oyend-de-Joux. From Oyend's abbey and from Lérins Sigismund of Burgundy, newly converted from Arianism, drew monks for the refounded house (St. Maurice's Abbey) that he established at Agaunum, c. 515–522. Many further abbots of Condat were canonised, as well as several monks of the sixth and seventh centuries.