AXL receptor tyrosine kinase

AXL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2C5D, 4RA0

Identifiers

Aliases

AXL, AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase

External IDs

MGI: 1347244 HomoloGene: 7583 GeneCards: AXL

Gene ontology
Molecular function	• nucleotide binding • protein kinase activity • transferase activity • virus receptor activity • kinase activity • protein heterodimerization activity • ATP binding • phosphatidylserine binding • protein binding • transmembrane receptor protein tyrosine kinase activity • phosphatidylinositol 3-kinase binding • myosin heavy chain binding • protein tyrosine kinase activity
Cellular component	• extracellular exosome • integral component of membrane • host cell surface • integral component of plasma membrane • cell surface • membrane • intracellular • plasma membrane • extracellular space
Biological process	• protein kinase B signaling • positive regulation of natural killer cell differentiation • apoptotic cell clearance • negative regulation of lymphocyte activation • spermatogenesis • negative regulation of apoptotic process • signal transduction • natural killer cell differentiation • negative regulation of interferon-gamma production • cellular response to lipopolysaccharide • secretion by cell • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • erythrocyte homeostasis • negative regulation of tumor necrosis factor production • positive regulation of protein kinase B signaling • viral process • positive regulation of cytokine-mediated signaling pathway • cellular response to interferon-alpha • forebrain cell migration • viral entry into host cell • negative regulation of dendritic cell apoptotic process • protein phosphorylation • cellular response to extracellular stimulus • enzyme linked receptor protein signaling pathway • positive regulation of pinocytosis • negative regulation of neuron apoptotic process • vagina development • ovulation cycle • innate immune response • blood vessel remodeling • cell maturation • dendritic cell differentiation • platelet activation • cell differentiation • immune system process • inflammatory response • neuron migration • phosphorylation • cellular response to hydrogen peroxide • animal organ regeneration • phagocytosis • peptidyl-tyrosine phosphorylation • negative regulation of cytokine production • neutrophil clearance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


558


26362

Ensembl


ENSG00000167601


ENSMUSG00000002602

UniProt


P30530


Q00993

RefSeq (mRNA)


NM_001278599 NM_001699 NM_021913


NM_001190974 NM_001190975 NM_009465

RefSeq (protein)


NP_001265528 NP_001690 NP_068713


NP_033491.2 NP_001177903 NP_001177904 NP_033491

Location (UCSC)

Chr 19: 41.22 – 41.26 Mb

Chr 7: 25.76 – 25.79 Mb

PubMed search

NM_001278599
NM_001699
NM_021913

NM_001190974
NM_001190975
NM_009465

NP_001265528
NP_001690
NP_068713

NP_033491.2
NP_001177903
NP_001177904
NP_033491

...
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