AXIN1

AXIN1

Protein AXIN1 PDB 1dk8.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1

Identifiers

AXIN1, AXIN, PPP1R49, axin 1

External IDs

MGI: 1096327 HomoloGene: 2614 GeneCards: AXIN1

Gene ontology
Molecular function	• beta-catenin binding • protein homodimerization activity • I-SMAD binding • GTPase activator activity • signal transducer activity • protein binding • identical protein binding • enzyme binding • receptor signaling complex scaffold activity • SMAD binding • ubiquitin protein ligase binding • protein complex scaffold • protein kinase binding • armadillo repeat domain binding
Cellular component	• cytoplasm • cytosol • lateral plasma membrane • membrane • plasma membrane • perinuclear region of cytoplasm • cytoplasmic vesicle • nucleus • beta-catenin destruction complex • cell periphery
Biological process	• forebrain anterior/posterior pattern specification • negative regulation of fat cell differentiation • positive regulation of protein phosphorylation • olfactory placode formation • positive regulation of protein catabolic process • activation of JUN kinase activity • positive regulation of canonical Wnt signaling pathway • embryonic eye morphogenesis • negative regulation of Wnt signaling pathway • cellular protein complex assembly • positive regulation of JNK cascade • negative regulation of transcription elongation from RNA polymerase II promoter • positive regulation of peptidyl-serine phosphorylation • positive regulation of transcription, DNA-templated • multicellular organism development • optic placode formation • determination of left/right symmetry • canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation • positive regulation of ubiquitin-protein transferase activity • positive regulation of peptidyl-threonine phosphorylation • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • cytoplasmic microtubule organization • canonical Wnt signaling pathway • embryonic skeletal joint morphogenesis • axial mesoderm formation • positive regulation of protein ubiquitination • activation of protein kinase activity • muscle cell development • Wnt-activated signaling pathway involved in forebrain neuron fate commitment • negative regulation of canonical Wnt signaling pathway • signal transduction • apoptotic process • beta-catenin destruction complex disassembly • positive regulation of GTPase activity • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • beta-catenin destruction complex assembly • protein deubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE AXIN1 212849 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


8312


12005


ENSG00000103126


ENSMUSG00000024182


O15169


O35625

RefSeq (mRNA)


NM_003502 NM_181050


NM_001159598 NM_009733

RefSeq (protein)


NP_003493 NP_851393


NP_033863.2 NP_001153070 NP_033863

Location (UCSC)

Chr 16: 0.29 – 0.35 Mb

Chr 17: 26.14 – 26.2 Mb

PubMed search

1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1

ENSG00000103126

ENSMUSG00000024182

NM_003502
NM_181050

NM_001159598
NM_009733

NP_003493
NP_851393

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Wikipedia

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