ATXN3

ATXN3

Protein ATXN3 PDB 1yzb.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YZB, 2AGA, 2DOS, 2JRI, 2KLZ, 4WTH, 4YS9

Identifiers

ATXN3, AT3, ATX3, JOS, MJD, MJD1, SCA3, Ataxin 3

External IDs

MGI: 1099442 HomoloGene: 3658 GeneCards: ATXN3

Genetically Related Diseases

coronary artery disease, orofacial cleft

Gene ontology
Molecular function	• Lys63-specific deubiquitinase activity • cysteine-type peptidase activity • ATPase binding • Lys48-specific deubiquitinase activity • peptidase activity • protein binding • identical protein binding • hydrolase activity • thiol-dependent ubiquitin-specific protease activity • thiol-dependent ubiquitinyl hydrolase activity • ubiquitin protein ligase binding
Cellular component	• endoplasmic reticulum membrane • nuclear matrix • nucleoplasm • nucleus • nucleolus • cytosol • plasma membrane • cytoplasm • mitochondrial matrix • mitochondrial membrane • nuclear inclusion body
Biological process	• nucleotide-excision repair • regulation of transcription, DNA-templated • protein K48-linked deubiquitination • positive regulation of ERAD pathway • transcription, DNA-templated • nervous system development • proteolysis • protein K63-linked deubiquitination • intermediate filament cytoskeleton organization • protein localization to cytosolic proteasome complex involved in ERAD pathway • microtubule cytoskeleton organization • actin cytoskeleton organization • chemical synaptic transmission • protein deubiquitination • ubiquitin-dependent protein catabolic process • misfolded or incompletely synthesized protein catabolic process • regulation of cell-substrate adhesion • cellular response to heat • monoubiquitinated protein deubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • cellular response to misfolded protein
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE ATXN3 205416 s at fs.png

PBB GE ATXN3 205415 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


4287


110616


ENSG00000066427


ENSMUSG00000021189


P54252 Q4VBR4


Q9CVD2

RefSeq (mRNA)

NM_001024631 NM_001127696 NM_001127697 NM_001164774 NM_001164776
NM_001164777 NM_001164778 NM_001164779 NM_001164780 NM_001164781 NM_001164782 NM_004993 NM_030660


NM_001167914 NM_029705

RefSeq (protein)

NP_001121168 NP_001121169 NP_001158246 NP_001158248 NP_001158249
NP_001158250 NP_001158251 NP_001158252 NP_001158253 NP_001158254 NP_004984 NP_109376


NP_083981.2 NP_001161386 NP_083981

Location (UCSC)

Chr 14: 92.04 – 92.11 Mb

Chr 12: 101.92 – 101.96 Mb

PubMed search

1YZB, 2AGA, 2DOS, 2JRI, 2KLZ, 4WTH, 4YS9

ENSG00000066427

ENSMUSG00000021189

NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660

NM_001167914
NM_029705

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Wikipedia

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