ATRX

ATRX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JM1, 2LBM, 2LD1, 3QL9, 3QLA, 3QLC, 3QLN, 4W5A
Identifiers
Aliases	ATRX, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, MRX52, alpha thalassemia/mental retardation syndrome X-linked, chromatin remodeler
External IDs	MGI: 103067 HomoloGene: 416 GeneCards: ATRX
Gene ontology Molecular function • DNA binding • nucleotide binding • chromo shadow domain binding • helicase activity • histone binding • metal ion binding • DNA translocase activity • methylated histone binding • DNA helicase activity • protein binding • hydrolase activity • ATP binding • chromatin binding Cellular component • telomeric heterochromatin • PML body • nuclear subtelomeric heterochromatin • SWI/SNF superfamily-type complex • pericentric heterochromatin • chromosome • nuclear heterochromatin • heterochromatin • nuclear chromosome • chromosome, telomeric region • nuclear chromosome, telomeric region • condensed nuclear chromosome, centromeric region • nucleus • nucleoplasm • nuclear body • nuclear pericentric heterochromatin Biological process • chromatin remodeling • nucleosome assembly • DNA recombination • post-embryonic forelimb morphogenesis • regulation of transcription, DNA-templated • multicellular organism growth • DNA damage response, signal transduction by p53 class mediator • positive regulation of nuclear cell cycle DNA replication • Sertoli cell development • transcription, DNA-templated • protein localization to chromosome, telomeric region • cellular response to DNA damage stimulus • positive regulation of telomeric RNA transcription from RNA pol II promoter • positive regulation of telomere maintenance • DNA methylation • negative regulation of telomeric RNA transcription from RNA pol II promoter • seminiferous tubule development • spermatogenesis • replication fork processing • negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric • DNA replication-independent nucleosome assembly • forebrain development • DNA repair • cellular response to hydroxyurea • positive regulation of transcription from RNA polymerase II promoter • DNA duplex unwinding • regulation of histone H3-K9 trimethylation • covalent chromatin modification • meiotic spindle organization • chromosome organization involved in meiotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	546	22589
Ensembl	ENSG00000085224	ENSMUSG00000031229
UniProt	P46100	Q61687
RefSeq (mRNA)	NM_000489 NM_138270 NM_138271	NM_009530
RefSeq (protein)	NP_000480 NP_612114	NP_033556
Location (UCSC)	Chr X: 77.5 – 77.79 Mb	Chr X: 105.8 – 105.93 Mb
PubMed search

2JM1, 2LBM, 2LD1, 3QL9, 3QLA, 3QLC, 3QLN, 4W5A

546

22589

ENSG00000085224

ENSMUSG00000031229

P46100

Q61687

NM_000489
NM_138270
NM_138271

NM_009530

NP_000480
NP_612114

NP_033556

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.

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Wikipedia