ATP1A3

ATP1A3
Identifiers
Aliases	ATP1A3, AHC2, DYT12, RDP, CAPOS, ATPase Na+/K+ transporting subunit alpha 3, ATP1A1
External IDs	MGI: 88107 HomoloGene: 113729 GeneCards: ATP1A3
Gene ontology Molecular function • steroid hormone binding • nucleotide binding • chaperone binding • sodium:potassium-exchanging ATPase activity • metal ion binding • sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential • heparan sulfate proteoglycan binding • D1 dopamine receptor binding • hydrolase activity • ATP binding • beta-amyloid binding Cellular component • cytoplasm • integral component of membrane • dendritic spine neck • extracellular vesicle • Golgi apparatus • membrane • myelin sheath • plasma membrane • synapse • sodium:potassium-exchanging ATPase complex • axon • dendritic spine head • endoplasmic reticulum • sarcolemma • nucleus Biological process • visual learning • cellular response to steroid hormone stimulus • regulation of cardiac conduction • cardiac muscle contraction • sodium ion transport • cellular sodium ion homeostasis • adult locomotory behavior • sodium ion export from cell • cell communication by electrical coupling involved in cardiac conduction • response to glycoside • ion transport • memory • cellular potassium ion homeostasis • potassium ion transport • ion transmembrane transport • ionotropic glutamate receptor signaling pathway • potassium ion import • transport • regulation of cardiac muscle cell membrane potential • response to drug • establishment or maintenance of transmembrane electrochemical gradient • cerebral cortex development • cellular response to retinoic acid • ATP hydrolysis coupled transmembrane transport • cellular response to thyroid hormone stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	478	232975
Ensembl	ENSG00000105409	ENSMUSG00000040907
UniProt	P13637	Q6PIC6
RefSeq (mRNA)	NM_001256213 NM_001256214 NM_152296	NM_001290469 NM_144921
RefSeq (protein)	NP_001243142 NP_001243143 NP_689509	NP_001277398.1 NP_001277398
Location (UCSC)	Chr 19: 41.97 – 42 Mb	Chr 7: 24.98 – 25.01 Mb
PubMed search

478

232975

ENSG00000105409

ENSMUSG00000040907

P13637

Q6PIC6

NM_001256213
NM_001256214
NM_152296

NM_001290469
NM_144921

NP_001243142
NP_001243143
NP_689509

NP_001277398.1
NP_001277398

Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene.

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

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Wikipedia