ATP13A2

ATP13A2
Identifiers
Aliases	ATP13A2, CLN12, HSA9947, KRPPD, PARK9, ATPase 13A2, SPG78
External IDs	MGI: 1922022 HomoloGene: 56940 GeneCards: ATP13A2
Gene ontology Molecular function • nucleotide binding • metal ion binding • ATPase activity • protein binding • hydrolase activity • ATP binding • cupric ion binding • phosphatidic acid binding • zinc ion binding • phosphatidylinositol-3,5-bisphosphate binding • manganese ion binding • calcium-transporting ATPase activity • cation-transporting ATPase activity Cellular component • integral component of membrane • membrane • vesicle membrane • integral component of plasma membrane • transport vesicle • lysosomal lumen • lysosome • vesicle • multivesicular body • neuron projection • integral component of lysosomal membrane • multivesicular body membrane • autophagosome • late endosome • neuronal cell body • lysosomal membrane Biological process • cellular cation homeostasis • cation transport • ion transmembrane transport • regulation of mitophagy • regulation of autophagosome size • regulation of endopeptidase activity • regulation of mitochondrion organization • cellular response to oxidative stress • cellular calcium ion homeostasis • cellular response to manganese ion • cellular iron ion homeostasis • protein autophosphorylation • cellular zinc ion homeostasis • polyamine import • autophagosome organization • regulation of glucosylceramidase activity • regulation of chaperone-mediated autophagy • negative regulation of neuron death • zinc ion homeostasis • regulation of macroautophagy • regulation of intracellular protein transport • positive regulation of protein secretion • positive regulation of exosomal secretion • peptidyl-aspartic acid autophosphorylation • negative regulation of lysosomal protein catabolic process • cellular response to zinc ion • calcium ion transmembrane transport • ATP hydrolysis coupled cation transmembrane transport • regulation of lysosomal protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23400	74772
Ensembl	ENSG00000159363	ENSMUSG00000036622
UniProt	Q9NQ11 Q8N4D4	Q9CTG6
RefSeq (mRNA)	NM_001141973 NM_001141974 NM_022089	NM_001164366 NM_029097
RefSeq (protein)	NP_001135445 NP_001135446 NP_071372 NP_001135445.1 NP_001135446.1	NP_083373.2 NP_001157838 NP_083373
Location (UCSC)	Chr 1: 16.99 – 17.01 Mb	Chr 4: 140.99 – 141.01 Mb
PubMed search

23400

74772

ENSG00000159363

ENSMUSG00000036622

Q9NQ11
Q8N4D4

Q9CTG6

NM_001141973
NM_001141974
NM_022089

NM_001164366
NM_029097

NP_001135445
NP_001135446
NP_071372
NP_001135445.1
NP_001135446.1

NP_083373.2
NP_001157838
NP_083373

Probable cation-transporting ATPase 13A2 is an enzyme that in humans is encoded by the ATP13A2 gene that is involved in the transport of divalent transition metal cations. It appears to protect cells from manganese and zinc toxicity, possibly by causing cellular efflux and/or lysosomal sequestration. However, it potentiates the toxic effects of cadmium and nickel on developing neurites.

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