ATOH1

ATOH1
Identifiers
Aliases	ATOH1, ATH1, HATH1, MATH-1, bHLHa14, atonal bHLH transcription factor 1
External IDs	MGI: 104654 HomoloGene: 31297 GeneCards: ATOH1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin DNA binding Cellular component • nucleus Biological process • Notch signaling pathway • regulation of neuron differentiation • auditory receptor cell fate determination • cell differentiation • positive regulation of auditory receptor cell differentiation • regulation of transcription, DNA-templated • positive regulation of inner ear receptor cell differentiation • negative regulation of apoptotic process • neuron migration • auditory receptor cell fate specification • transcription, DNA-templated • nervous system development • axon guidance • multicellular organism development • central nervous system development • brain development • auditory receptor cell differentiation • inner ear morphogenesis • positive regulation of neuron differentiation • neuron differentiation • cerebral cortex development • inner ear development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	474	11921
Ensembl	ENSG00000172238	ENSMUSG00000073043
UniProt	Q92858	P48985
RefSeq (mRNA)	NM_005172	NM_007500
RefSeq (protein)	NP_005163	NP_031526
Location (UCSC)	Chr 4: 93.83 – 93.83 Mb	Chr 6: 64.73 – 64.73 Mb
PubMed search

474

11921

ENSG00000172238

ENSMUSG00000073043

Q92858

P48985

NM_005172

NM_007500

NP_005163

NP_031526

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a "cancer switch-off" gene. [1]

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