ATN1

ATN1
Identifiers
Aliases	ATN1, B37, D12S755E, DRPLA, HRS, NOD, atrophin 1
External IDs	OMIM: 607462 MGI: 104725 HomoloGene: 1461 GeneCards: ATN1
Gene ontology Molecular function • protein binding • transcription corepressor activity • protein domain specific binding Cellular component • nuclear matrix • perinuclear region of cytoplasm • cell junction • nucleoplasm • cytoplasm • nucleus Biological process • neuron apoptotic process • central nervous system development • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1822	13498
Ensembl	ENSG00000111676	ENSMUSG00000004263
UniProt	P54259	O35126
RefSeq (mRNA)	NM_001940 NM_001007026	NM_007881
RefSeq (protein)	NP_001007027 NP_001931	NP_031907.2 NP_031907
Location (UCSC)	Chr 12: 6.92 – 6.94 Mb	Chr 6: 124.74 – 124.76 Mb
PubMed search

1822

13498

ENSG00000111676

ENSMUSG00000004263

P54259

O35126

NM_001940
NM_001007026

NM_007881

NP_001007027
NP_001931

NP_031907.2
NP_031907

Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. The function of Atrophin-1 has not yet been determined. There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional co-repressor. Atrophin-1 can be found in the nuclear and cytoplasmic compartments of neurons. It is expressed in nervous tissue.

The function of Atrophin-1 have not been defined yet. It is widely hypothesized that Atrophin-1 functions as a transcriptional co-repressor. A transcriptional co-repressor is a protein that indirectly suppresses the activity of specific genes by interacting with DNA-binding proteins.

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Wikipedia