ATG4A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2P82

Identifiers

Aliases

ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase

External IDs

MGI: 2147903 HomoloGene: 70873 GeneCards: ATG4A

Gene ontology
Molecular function	• peptidase activity • cysteine-type peptidase activity • protein binding • hydrolase activity • cysteine-type endopeptidase activity
Cellular component	• cytoplasm • cytosol
Biological process	• autophagy • protein transport • nucleophagy • C-terminal protein lipidation • protein delipidation • mitophagy • autophagosome assembly • proteolysis • protein targeting to membrane • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


115201


666468

Ensembl


ENSG00000101844


ENSMUSG00000079418

UniProt


Q8WYN0


Q8C9S8

RefSeq (mRNA)

NM_052936 NM_178270 NM_178271 NM_001321287 NM_001321288
NM_001321289 NM_001321290


NM_174875

RefSeq (protein)

NP_001308216 NP_001308217 NP_001308218 NP_001308219 NP_443168
NP_840054 NP_840055


NP_777364

Location (UCSC)

Chr X: 108.09 – 108.15 Mb

Chr X: 140.96 – 141.16 Mb

PubMed search

NM_001321289
NM_001321290

NM_174875

NP_840054
NP_840055

NP_777364

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.

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Wikipedia