ATF6

ATF6
Identifiers
Aliases	ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs	MGI: 1926157 HomoloGene: 32015 GeneCards: ATF6
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription regulatory region sequence-specific DNA binding • protein binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • cAMP response element binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • integral component of membrane • Golgi apparatus • nuclear envelope • membrane • endoplasmic reticulum membrane • Golgi membrane • nucleoplasm • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • nucleus • cytosol Biological process • eye development • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • regulation of transcription from RNA polymerase II promoter • response to stress • GO:0006350 transcription, DNA-templated • endoplasmic reticulum unfolded protein response • ATF6-mediated unfolded protein response • response to unfolded protein • protein folding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • signal transduction • visual perception • positive regulation of apoptotic process • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22926	226641
Ensembl	ENSG00000118217	ENSMUSG00000026663
UniProt	P18850	F6VAN0
RefSeq (mRNA)	NM_007348	NM_001081304
RefSeq (protein)	NP_031374	NP_001074773.1 NP_001074773
Location (UCSC)	Chr 1: 161.77 – 161.96 Mb	Chr 1: 170.7 – 170.87 Mb
PubMed search

22926

226641

ENSG00000118217

ENSMUSG00000026663

P18850

F6VAN0

NM_007348

NM_001081304

NP_031374

NP_001074773.1
NP_001074773

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

ATF6 has been shown to interact with YY1 and Serum response factor.

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Wikipedia