ATF5

ATF5
Identifiers
Aliases	ATF5, ATFX, HMFN0395, activating transcription factor 5
External IDs	MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • tubulin binding • kinase binding • protein binding • transcription regulatory region DNA binding Cellular component • centrosome • transcription factor complex • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus • cytoplasm • cytosol Biological process • negative regulation of cell cycle G2/M phase transition • regulation of transcription, DNA-templated • olfactory bulb interneuron differentiation • multicellular organism growth • regulation of transcription from RNA polymerase II promoter • negative regulation of apoptotic process • post-embryonic development • transcription, DNA-templated • cerebellar granule cell precursor proliferation • positive regulation of transcription, DNA-templated • regulation of centrosome cycle • circadian rhythm • olfactory bulb interneuron development • regulation of gene expression • olfactory lobe development • negative regulation of transcription, DNA-templated • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22809	107503
Ensembl	ENSG00000169136	ENSMUSG00000038539
UniProt	Q9Y2D1	O70191
RefSeq (mRNA)	NM_001193646 NM_001290746 NM_012068	NM_030693
RefSeq (protein)	NP_001180575 NP_001277675 NP_036200	NP_109618.1 NP_109618
Location (UCSC)	Chr 19: 49.93 – 49.93 Mb	Chr 7: 44.81 – 44.82 Mb
PubMed search

22809

107503

ENSG00000169136

ENSMUSG00000038539

Q9Y2D1

O70191

NM_001193646
NM_001290746
NM_012068

NM_030693

NP_001180575
NP_001277675
NP_036200

NP_109618.1
NP_109618

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.

First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

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Wikipedia