ASPM (gene)

ASPM
Identifiers
Aliases	ASPM, ASP, Calmbp1, MCPH5, abnormal spindle microtubule assembly
External IDs	OMIM: 605481 MGI: 1334448 HomoloGene: 7650 GeneCards: ASPM
Gene ontology Molecular function • calmodulin binding Cellular component • cytoplasm • mitotic spindle pole • spindle pole • meiotic spindle • spindle • midbody • microtubule • cytoskeleton • nucleus • microtubule minus-end Biological process • positive regulation of neuroblast proliferation • maintenance of centrosome location • male gonad development • negative regulation of neuron differentiation • forebrain neuroblast division • positive regulation of canonical Wnt signaling pathway • regulation of meiotic cell cycle • neuron migration • oogenesis • neuronal stem cell population maintenance • cell division • brain development • spindle organization • developmental growth • spermatogenesis • negative regulation of asymmetric cell division • cerebral cortex development • cell cycle • spindle localization • spindle assembly involved in meiosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	259266	12316
Ensembl	ENSG00000066279	ENSMUSG00000033952
UniProt	Q8IZT6	Q8CJ27
RefSeq (mRNA)	NM_018136 NM_001206846	NM_009791
RefSeq (protein)	NP_001193775 NP_060606	NP_033921.3 NP_033921
Location (UCSC)	Chr 1: 197.08 – 197.15 Mb	Chr 1: 139.45 – 139.49 Mb
PubMed search

259266

12316

ENSG00000066279

ENSMUSG00000033952

Q8IZT6

Q8CJ27

NM_018136
NM_001206846

NM_009791

NP_001193775
NP_060606

NP_033921.3
NP_033921

Abnormal spindle-like microcephaly-associated protein also known as abnormal spindle protein homolog or Asp homolog is a protein that in humans is encoded by the ASPM gene. ASPM is located on chromosome 1, band q31 (1q31). Defective forms of the ASPM gene are associated with autosomal recessive primary microcephaly.

"ASPM" is an acronym for "Abnormal Spindle-like, Microcephaly-associated", which reflects its being an ortholog to the Drosophila melanogaster "abnormal spindle" (asp) gene. The expressed protein product of the asp gene is essential for normal mitotic spindle function in embryonic neuroblasts and regulation of neurogenesis.

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