ASIC3

ASIC3
Identifiers
Aliases	ASIC3, ACCN3, DRASIC, SLNAC1, TNaC1, acid sensing ion channel subunit 3
External IDs	MGI: 2159339 HomoloGene: 20999 GeneCards: ASIC3
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 151,048,292 bp End 151,052,756 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 24,413,392 bp End 24,417,835 bp
Gene ontology Molecular function • PDZ domain binding • enterobactin transporter activity • sodium channel activity • cation channel activity • ligand-gated sodium channel activity • acid-sensing ion channel activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • detection of temperature stimulus involved in sensory perception • sensory perception • sodium ion transmembrane transport • detection of chemical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sodium ion transport • enterobactin transport • response to mechanical stimulus • cation transport • response to heat • sensory perception of sour taste • ion transport • detection of chemical stimulus involved in sensory perception • cation transmembrane transport • detection of temperature stimulus involved in sensory perception of pain • ion transmembrane transport • signal transduction • response to acidic pH • detection of mechanical stimulus involved in sensory perception of pain • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9311	171209
Ensembl	ENSG00000213199	ENSMUSG00000038276
UniProt	Q9UHC3	Q6X1Y6
RefSeq (mRNA)	NM_004769 NM_020321 NM_020322	NM_183000 NM_001310474
RefSeq (protein)	NP_004760 NP_064717 NP_064718	NP_001297403 NP_892045
Location (UCSC)	Chr 7: 151.05 – 151.05 Mb	Chr 7: 24.41 – 24.42 Mb
PubMed search

9311

171209

ENSG00000213199

ENSMUSG00000038276

Q9UHC3

Q6X1Y6

NM_004769
NM_020321
NM_020322

NM_183000
NM_001310474

NP_004760
NP_064717
NP_064718

NP_001297403
NP_892045

Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1998. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

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